Featured Research

from universities, journals, and other organizations

Chlamydia Vaccine: Early Animal Trials Show Promise

Date:
February 21, 2007
Source:
University of Texas at San Antonio
Summary:
The University of Texas at San Antonio and the University of Texas Health Science Center at San Antonio have had success in early trials to discover a vaccine that will prevent chlamydia -- the most common bacteria-related sexually transmitted disease in the United States.

UTSA Postdoctoral Fellow Ashlesh Murthy is finding success developing a chlamydia vaccine. (Credit: Mark McClendon)
Credit: Mark McClendon

It's the most common bacteria-related sexually transmitted disease in the United States, so researchers at The University of Texas at San Antonio's South Texas Center for Emerging Infectious Diseases (STCEID) and The University of Texas at San Antonio Health Science Center have partnered to discover a vaccine that will prevent Chlamydia.

According to the Centers for Disease Control and Prevention (CDC), Chlamydia is a common sexually transmitted disease caused by the bacterium, Chlamydia trachomatis, which can damage a woman's reproductive organs. In women, symptoms are usually mild or absent. Serious complications can cause irreversible damage, including infertility, before a woman ever recognizes a problem. In men, Chlamydia complications can also cause discharge from the penis of an infected male.

The most recent report from the CDC indicates 930,000 cases of Chlamydial infection were reported in the United States in 2004. It's estimated annually, that the number of new cases of Chlamydia infection has risen to more than 2.8 million.

After three years of trial-and-error, Ashlesh Murthy, a post-doctoral student in the UTSA Cell and Molecular Biology program has found success in administering a chlamydial prevention vaccine in mouse models. The next step will be to test the vaccine in larger animals, primarily guinea pigs.

"This is a very prevalent disease in women throughout the world and the biggest problem is that most infected women never show any symptoms, so they never get treated," said Murthy. "When Chlamydia is left untreated, it can lead to severe complications including pelvic-inflammatory disease, ectopic pregnancies and infertility."

Murthy's research is guided by Bernard Arulanandam, an associate professor of biology who began studying Chlamydia six years ago.

"With the recent success of the human papilloma virus vaccine, developed to prevent cervical cancer in young women, I think the urgency to develop a Chlamydia prevention vaccine is on the horizon," said Arulanandam.

The UTSA researchers have been working with Guangming Zhong, a professor of microbiology at UTHSC, whose lab has been identifying antigens or proteins in Chlamydia as vaccine candidates and providing them for the UTSA researchers to analyze for their efficacy.

Collaborating together is nothing new for Arulanandam and Murthy. The pair have worked together since 2003 when Murthy enrolled in UTSA's first cell and molecular biology doctoral program. In May 2006, Murthy was UTSA's first recipient of a doctoral degree in cell and molecular biology.

Arulanandam is one of 19 faculty members in UTSA's new South Texas Center for Emerging Infectious Diseases. The center researchers focus on critical areas of human health including anthrax, tularemia, cholera, Lyme disease, desert valley fever and other parasitic and fungal diseases.

The University of Texas at San Antonio is one of the premier institutions of higher education in South Texas and one of the fastest growing universities in the state. One of nine academic universities and six health institutions that comprise the UT System, UTSA is the second largest institution in the system. Celebrating its 37th anniversary, UTSA serves more than 28,300 students enrolled in 62 bachelor's, 43 master's and 20 doctoral degree programs.

The University of Texas Health Science Center at San Antonio is the leading research institution in South Texas and one of the major health sciences universities in the world. With an operating budget of $536 million, the Health Science Center is the chief catalyst for the $14.3 billion biosciences and health care industry, the leading sector in San Antonio's economy. The Health Science Center has had an estimated $35 billion impact on the region since inception and has expanded to six campuses in San Antonio, Laredo, Harlingen and Edinburg.


Story Source:

The above story is based on materials provided by University of Texas at San Antonio. Note: Materials may be edited for content and length.


Cite This Page:

University of Texas at San Antonio. "Chlamydia Vaccine: Early Animal Trials Show Promise." ScienceDaily. ScienceDaily, 21 February 2007. <www.sciencedaily.com/releases/2007/02/070220012912.htm>.
University of Texas at San Antonio. (2007, February 21). Chlamydia Vaccine: Early Animal Trials Show Promise. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/02/070220012912.htm
University of Texas at San Antonio. "Chlamydia Vaccine: Early Animal Trials Show Promise." ScienceDaily. www.sciencedaily.com/releases/2007/02/070220012912.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins