Featured Research

from universities, journals, and other organizations

Estrogen Gene Affects Risk Of Breast Cancer, But Not CVD

Date:
February 28, 2007
Source:
American Heart Association
Summary:
A large Danish study rebuts the accepted idea that differences in an estrogen gene (ESR1) affect the risk of heart attack and stroke in response to hormone replacement therapy. However, the study -- published in Circulation: Journal of the American Heart Association -- found that the gene may be associated with an increased risk of breast cancer.

A large Danish study rebuts the accepted idea that differences in an estrogen gene (ESR1) affect the risk of heart attack and stroke in response to hormone replacement therapy. However, the study -- published in Circulation: Journal of the American Heart Association -- found that the gene may be associated with an increased risk of breast cancer. The two forms of the ESR1 gene, called alleles, are the C allele and the T allele. A person has two copies of any gene; thus, someone can have two copies of the C allele (CC), two of the T allele (TT), or one of each (CT).

Estrogens are important hormones that take action when they come in contact with estrogen receptors on the body's cells. They influence multiple organ systems in men and women, including cardiovascular, reproductive and skeletal systems. Therefore, genetic differences in estrogen receptors could influence risk of cardiovascular disease (CVD), cancer of reproductive organs and osteoporosis-linked bone fracture in the presence of supplemental hormone therapy.

In the largest and statistically most powerful study addressing whether risk of disease is associated with ESR1 gene type, researchers followed 2,495 patients with ischemic heart disease, 856 with ischemic cerebrovascular disease (including stroke) and 1,256 with breast cancer for up to 25 years. They also gathered data on 9,244 people from the Danish general population.

The researchers compared rates of CVD (heart attack, angina, stroke, venous thromboembolism), cancer of reproductive organs (breasts, ovaries, uterus and prostate), and hip fracture among the different groups, according to their ESR1 gene type. In the general population, 21 percent of people were CC, 50 percent were CT and 29 percent were TT.

The researchers found that differences in the ESR1 receptor gene do not influence high density lipoprotein cholesterol response to hormone replacement therapy or risk of CVD, most cancers of reproductive organs or hip fracture. However, the odds for breast cancer in women with TT were 40 percent higher than in women with CC.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Estrogen Gene Affects Risk Of Breast Cancer, But Not CVD." ScienceDaily. ScienceDaily, 28 February 2007. <www.sciencedaily.com/releases/2007/02/070220014141.htm>.
American Heart Association. (2007, February 28). Estrogen Gene Affects Risk Of Breast Cancer, But Not CVD. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/02/070220014141.htm
American Heart Association. "Estrogen Gene Affects Risk Of Breast Cancer, But Not CVD." ScienceDaily. www.sciencedaily.com/releases/2007/02/070220014141.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins