Featured Research

from universities, journals, and other organizations

Cells In The Lung Clear The Air To Prevent Lung Damage

Date:
March 5, 2007
Source:
Journal of Clinical Investigation
Summary:
Air pollution and tobacco smoke contain oxidants that when inhaled can cause damage to the lungs and contribute to diseases such as asthma and chronic obstructive pulmonary disease (COPD). In a study that appears in the March issue of the Journal of Clinical Investigation, researchers from the Harvard School of Public Health, Boston, identify a new mechanism by which mice are protected against inhaled oxidants.

Air pollution and tobacco smoke contain oxidants that when inhaled can cause damage to the lungs and contribute to diseases such as asthma and chronic obstructive pulmonary disease (COPD). In a study that appears in the March issue of the Journal of Clinical Investigation, researchers from the Harvard School of Public Health, Boston, identify a new mechanism by which mice are protected against inhaled oxidants.

Lester Kobzik and colleagues observed that immune cells in the lungs (known as alveolar macrophages) of mice resistant to lung damage caused by the oxidant ozone expressed more of a protein known as MARCO than the alveolar macrophages of mice susceptible to ozone-induced lung damage.

Consistent with a role for MARCO in protection from oxidant-induced lung damage, mice lacking MARCO showed more lung damage when exposed to either ozone or another oxidant than mice expressing normal amounts of MARCO. MARCO provided protection by enabling alveolar macrophages to take up lipids in the lung modified by the oxidant that would initiate an inflammatory reaction if not removed.

A similar role in the removal of lipids in the lung modified by these oxidants was identified for another protein related to MARCO, SR-AI/II.

As discussed in an accompanying commentary by Edward Postlethwait from the University of Alabama at Birmingham, it is now important to determine whether similar functions can be ascribed to these and other related proteins (all of which are known as scavenger receptors) in humans because of the extensive morbidity associated with lung diseases such as asthma and COPD.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Cells In The Lung Clear The Air To Prevent Lung Damage." ScienceDaily. ScienceDaily, 5 March 2007. <www.sciencedaily.com/releases/2007/03/070302082829.htm>.
Journal of Clinical Investigation. (2007, March 5). Cells In The Lung Clear The Air To Prevent Lung Damage. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2007/03/070302082829.htm
Journal of Clinical Investigation. "Cells In The Lung Clear The Air To Prevent Lung Damage." ScienceDaily. www.sciencedaily.com/releases/2007/03/070302082829.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins