Featured Research

from universities, journals, and other organizations

New Evidence For Receptor's Role In Alcohol Pleasure And Problems

Date:
March 9, 2007
Source:
NIH/National Institute on Alcohol Abuse and Alcoholism
Summary:
A genetic variant of a receptor in the brain's reward circuitry heightens the stimulating effects of early exposures to alcohol and increases alcohol consumption, according to a new study by NIAAA researchers. Conducted in rhesus monkeys, the study extends previous research that suggests an important role for a similar brain receptor variant in the development of human alcohol use disorders.

A genetic variant of a receptor in the brain's reward circuitry heightens the stimulating effects of early exposures to alcohol and increases alcohol consumption, according to a new study by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH).

Related Articles


Conducted in rhesus monkeys, the study extends previous research that suggests an important role for a similar brain receptor variant in the development of human alcohol use disorders. A report of the findings is published in the March, 2007 issue of the Archives of General Psychiatry.

"Although the pathway to alcoholism is influenced by many factors, our findings affirm that individuals who possess this receptor variant may experience enhanced pleasurable effects from alcohol that could increase their risk for developing alcohol abuse and dependence," notes Markus Heilig, M.D., Ph.D., NIAAA Clinical Director and the study's senior author.

Molecules known as opioid peptides bind to opioid receptors in the brain to signal experiences of reward and reinforcement, as well as the euphoria and other positive subjective effects produced by alcohol. Previous studies have shown that, among the brain's various subtypes of opioid receptors, the mu-subtype is most likely responsible for transmitting alcohol's positive effects.

"We also know that there are several genetic variants of the human mu-opioid receptor," notes first author Christina Barr, V.M.D., Ph.D., a lead investigator in NIAAA's Laboratory of Clinical and Translational Studies and Laboratory of Neurogenetics. "One of these, designated 118G, has a greatly enhanced ability to bind opioid peptides. People who have this variant of the receptor have reported increased euphoria following alcohol consumption."

Drs. Barr, Heilig, and their colleagues note that recent studies have linked the 118G mu-opioid receptor with alcohol dependence in humans. In the current study, the researchers explored the link between genetic variants of mu-opioid receptors and alcohol-related behaviors in a group of 82 rhesus monkeys.

"A mu-opioid receptor variant that is functionally similar to the human 118G variant occurs in these animals," explained Dr. Barr. "That is, it also has a greatly enhanced ability to bind opioid peptides. We hypothesized that monkeys that had the gene for this receptor variant would experience enhanced alcohol stimulation and, therefore, consumption.

Groups of monkeys had access to both alcoholic and non-alcoholic solutions for one hour per day for a period of six weeks. Researchers measured the animals' alcohol intake and post-intake activity, and determined which monkeys carried the gene for the mu-opioid receptor similar to the human 118G receptor. Activity measures are commonly used in animal studies to assess alcohol's pleasurable effects.

As predicted, the researchers found that monkeys with the variant gene showed increased activity following alcohol consumption. They also found that male animals with the variant had a clear preference for the alcohol solution and consumed on average almost twice as much alcohol as other animals. Males with the variant also became intoxicated on almost 30 percent of testing days, while other animals did so only on an average of 8 percent of testing days.

"The male-restricted effect of this gene is interesting, and parallels other recent evidence that opioid transmission may play a greater role in alcohol problems among some males than among females," explained Dr. Heilig. This information also complements recent data suggesting that alcohol-dependent people with the gene for the 118G receptor have a better therapeutic response to medications that block opioid receptors. More broadly, the finding underscores the important role that the pleasurable and stimulating initial effects of alcohol play in the subsequent development of alcohol problems."


Story Source:

The above story is based on materials provided by NIH/National Institute on Alcohol Abuse and Alcoholism. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute on Alcohol Abuse and Alcoholism. "New Evidence For Receptor's Role In Alcohol Pleasure And Problems." ScienceDaily. ScienceDaily, 9 March 2007. <www.sciencedaily.com/releases/2007/03/070307075508.htm>.
NIH/National Institute on Alcohol Abuse and Alcoholism. (2007, March 9). New Evidence For Receptor's Role In Alcohol Pleasure And Problems. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2007/03/070307075508.htm
NIH/National Institute on Alcohol Abuse and Alcoholism. "New Evidence For Receptor's Role In Alcohol Pleasure And Problems." ScienceDaily. www.sciencedaily.com/releases/2007/03/070307075508.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins