Featured Research

from universities, journals, and other organizations

Computer Key Unlocks Heritable Disorders

Date:
March 8, 2007
Source:
Technical University of Denmark
Summary:
Danish and Belgian researchers have found a computer key that maps genes underlying heritable disorders, such as breast cancer, multiple sclerosis, and Alzheimer's disease. These results will possibly ease the discovery of new medicines and improve treatment in various disorders.

Danish and Belgian researchers have found a computer key that maps genes underlying heritable disorders, such as breast cancer, multiple sclerosis, and Alzheimer’s disease. These results will possibly ease the discovery of new medicines and improve treatment in various disorders.

The results – which are published in the current issue of Nature Biotechnology – show that genes important for the development of diseases like Alzheimer’s follow the same cellular rules as genes involved in fundamentally different disorders, such as heart disorders, multiple sclerosis, breast cancer, and Type 2 diabetes.

”Many disorders manifest themselves in fundamentally different ways, but the new surprising discovery is that the underlying genes play together after the same rules. Our results show that the genes that trigger diseases, regardless of the type of disease in question, are social team players who cooperate according to highly specific rules. These rules have now been mapped, and we have pointed at hundreds of new genes that are likely to be involved in disorders including multiple sclerosis, Parkinson, heart disorders, and diabetes”, says Kasper Lage from Technical University of Denmark, who is the project coordinator on this work.

Heritable disorders will be easier to interpret for clinicians using the new results. Furthermore, the identification of new genes likely to be involved in disorders will help patients with defects in these genes. For example, if you are a high risk carrier of a gene that underlies a disease such as Type 2 diabetes, physicians could prevent or delay the manifestations of the disease by dietary guidance early in life.

”This is a crucial breakthrough for our understanding of heritable disorders, and a breakthrough for systems biology as a research strategy in the field genetics and disease”, says Sψren Brunak leader of Center for Biological Sequence analysis at the Technical University of Denmark. ”We work with genes and proteins, but also with clinical literature describing the characteristics of different disorders. Then we let the computer integrate all of these data, and extract the pattern”, he adds.

The results are the product of a collaboration between the Center for Biological Sequence analysis, the Wilhelm Johannsen Center for Functional Genomics, Steno Diabetes Center in Denmark, and the SymBioSys Center for Computational Systems Biology, Katholieke Universiteit Leuven in Belgium.


Story Source:

The above story is based on materials provided by Technical University of Denmark. Note: Materials may be edited for content and length.


Cite This Page:

Technical University of Denmark. "Computer Key Unlocks Heritable Disorders." ScienceDaily. ScienceDaily, 8 March 2007. <www.sciencedaily.com/releases/2007/03/070308074418.htm>.
Technical University of Denmark. (2007, March 8). Computer Key Unlocks Heritable Disorders. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2007/03/070308074418.htm
Technical University of Denmark. "Computer Key Unlocks Heritable Disorders." ScienceDaily. www.sciencedaily.com/releases/2007/03/070308074418.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) — A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) — That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) — Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) — The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins