Featured Research

from universities, journals, and other organizations

Mutation To Mismatch Repair Gene Associated With Colorectal Cancer

Date:
March 22, 2007
Source:
Journal of the National Cancer Institute
Summary:
Patients with a variant of a DNA repair gene, known as MLH1, may have an increased risk of a subtype of colorectal cancer, according to a study in the March 21 issue of the Journal of the National Cancer Institute.

Patients with a variant of a DNA repair gene, known as MLH1, may have an increased risk of a subtype of colorectal cancer, according to a study in the March 21 issue of the Journal of the National Cancer Institute.

Mismatch repair genes fix problems that arise during DNA replication when bases are incorrectly paired. Mutations in these repair genes are associated with increased risks of cancer.

Stavroula Raptis and Miralem Mrkonjic, graduate students at the University of Toronto, and colleagues analyzed two DNA mismatch repair genes, MLH1 and MSH2, in 1,359 colorectal cancer patients and 1,373 controls from Ontario and Newfoundland.

One particular variant in the MLH1 gene, -93G>A, was strongly associated with colorectal cancer. Patients with two copies of this version of the gene had a greater risk of colorectal cancer than patients with only one.

"Decreased levels of MLH1 expression associated with [MLH1 -93G>A] may lead to impaired cell cycle control, allowing cells to proceed with cell division before proper DNA repair can be accomplished. This impaired control would overwhelm the mismatch repair mechanism, leading to the accumulation of mutations," the authors write.

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jnci.oxfordjournals.org/.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Mutation To Mismatch Repair Gene Associated With Colorectal Cancer." ScienceDaily. ScienceDaily, 22 March 2007. <www.sciencedaily.com/releases/2007/03/070321161840.htm>.
Journal of the National Cancer Institute. (2007, March 22). Mutation To Mismatch Repair Gene Associated With Colorectal Cancer. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2007/03/070321161840.htm
Journal of the National Cancer Institute. "Mutation To Mismatch Repair Gene Associated With Colorectal Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/03/070321161840.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins