Featured Research

from universities, journals, and other organizations

Immunization Against Type 1 Diabetes: Mice Successfully Treated

Date:
May 28, 2007
Source:
Helmholtz Association
Summary:
Researchers have successfully treated type 1 diabetic mice with a vaccination. The vaccine they designed in this model included structures that the immune system mistakenly attacks in type 1 diabetes. The researchers showed that, in principle, it is possible to treat autoimmune diseases (diseases, in which the immune system attacks the own body) by inducing "active tolerance".

Researchers in France and Germany have successfully treated type 1 diabetic mice with a vaccination. The vaccine they designed in this model included structures that the immune system mistakenly attacks in type 1 diabetes.

Related Articles


The researchers showed that, in principle, it is possible to treat autoimmune diseases (diseases, in which the immune system attacks the own body) by inducing “active tolerance”. That means activating the immune system so that it no longer attacks the body’s own structures, but instead protects them from the immune attack.

Autoimmune diseases develop when the immune system can no longer distinguish between “non-self” and “self” and attacks the body’s own structures as is the case in type 1 diabetes. In this severe metabolic disorder, misguided T cells of the immune system destroy the cells of the pancreas that produce insulin, a hormone essential for life. The affected persons, who often develop the disease already during childhood, are subjected to insulin injections throughout their entire lives.

Previously in an experiment with mice, Drs. Falk and Rötzschke proved that it is possible to block the misdirected immune system. They vaccinated mice with modified structures of the same organ against which the immune system runs amok.

Structures which activate the immune system are referred to as antigens. The MDC researchers were able to show that the animals are protected from this autoimmune disease by means of the body’s own antigens linked together in a repetitive chain of identical copies. However, how and why this protective mechanism works was not clear.

Immunization with body’s own antigens opens up therapy for all autoimmune diseases.

In collaboration with Dr. Ronald S. Liblau in Toulouse, the two MDC researchers have now been able to prove that the protective effect of the immunization is due to the activation of the suppressor cells of the immune system. Suppressor cells block T cells.

However, suppressor cells raised against the body’s structures selectively inhibit only those T cells that attack the body’s own tissue. T cells that attack foreign structures such as viruses or bacteria remain unaffected by these suppressor cells. The immune system is thus again able to recognize the body’s own structures as “self” and tolerate them.

“That is why suppressor cells have re-emerged as a promising research focus in immunology,” Dr. Rötzschke pointed out. “Suppressing undesired immune reactions through specific immunizations with the body’s own antigens will open up a fundamental new approach to treatment.” The immunologist is convinced that it will be possible to treat not only type 1 diabetes but also other autoimmune diseases – both as prevention of the disease as well as therapy after disease onset.

The paper, Multimerized T cell epitopes protects from experimental autoimmune diabetes by inducing dominant tolerance, by Dr. Roland S. Liblau of INSERM (Institut national de la santé et de la recherche médicale) of Purpan University Hospital in Toulouse, France, and Dr. Kirsten Falk and Dr. Olaf Rötzschke of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, has now been published online in the American Proceedings of the National Academy of Sciences.


Story Source:

The above story is based on materials provided by Helmholtz Association. Note: Materials may be edited for content and length.


Cite This Page:

Helmholtz Association. "Immunization Against Type 1 Diabetes: Mice Successfully Treated." ScienceDaily. ScienceDaily, 28 May 2007. <www.sciencedaily.com/releases/2007/05/070527140321.htm>.
Helmholtz Association. (2007, May 28). Immunization Against Type 1 Diabetes: Mice Successfully Treated. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2007/05/070527140321.htm
Helmholtz Association. "Immunization Against Type 1 Diabetes: Mice Successfully Treated." ScienceDaily. www.sciencedaily.com/releases/2007/05/070527140321.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) — Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) — While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins