Featured Research

from universities, journals, and other organizations

Antibiotic Use In Infants Linked To Asthma

Date:
June 12, 2007
Source:
American College of Chest Physicians
Summary:
Children receiving antibiotics in the first year of life are shown at greater risk for developing asthma by age 7 than those not receiving antibiotics.

New research indicates that children who receive antibiotics before their first birthday are significantly more likely to develop asthma by age 7. The study, published in the June issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians (ACCP), reports that children receiving antibiotics in the first year of life were at greater risk for developing asthma by age 7 than those not receiving antibiotics. The risk for asthma doubled in children receiving antibiotics for nonrespiratory infections, as well as in children who received multiple antibiotic courses and who did not live with a dog during the first year.

"Antibiotics are prescribed mostly for respiratory tract infections, yet respiratory symptoms can be a sign of future asthma. This may make it difficult to attribute antibiotic use to asthma development," said lead study author Anita Kozyrskyj, PhD, University of Manitoba, Winnipeg, MB. "Our study reported on antibiotic use in children being treated for nonrespiratory tract infections, which distinguishes the effect of the antibiotic."

By using a prescription database, Dr. Kozyrskyj and colleagues from the University of Manitoba and McGill University in Montreal were able to monitor the antibiotic use of 13,116 children from birth to age 7, specifically noting antibiotic use during the first year of life and presence of asthma at 7. The reason for antibiotic use was categorized by lower respiratory tract infection (bronchitis, pneumonia), upper respiratory tract infection (otitis media, sinusitis), and nonrespiratory tract infection (urinary infections, impetigo).

Risk and protective factors also were noted, including gender, urban or rural location, neighborhood income, number of siblings at age 7, maternal history of asthma, and pets reported living in the home. Within the study group, 6 percent of children had current asthma at age 7, while 65 percent of children had received at least one antibiotic prescription during the first year of life. Of the prescriptions, 40 percent of children received antibiotics for otitis media, 28 percent for other upper respiratory tract infections, 19 percent for lower respiratory tract infections, and 7 percent for non-respiratory tract infections.

Results showed that antibiotic use in the first year was significantly associated with greater odds of asthma at age 7. This likelihood increased with the number of antibiotic courses, with children receiving more than four courses of antibiotics having 1.5 times the risk of asthma compared with children not receiving antibiotics. When researchers compared the reason for antibiotic use, their analysis indicated that asthma at age 7 was almost twice as likely in children receiving an antibiotic for nonrespiratory tract infections compared with children who did not receive antibiotics.

Maternal asthma and presence of a dog during the first year of life were both associated with asthma risk. Children who received multiple antibiotic courses and who were born to women without a history of asthma were twice as likely to develop asthma than those not receiving antibiotics. Furthermore, absence of a dog during the birth-year doubled asthma risk among children taking multiple courses of antibiotics.

"Dogs bring germs into the home, and it is thought that this exposure is required for the infant's immune system to develop normally. Other research has shown that the presence of a dog in early life protects against the development of asthma," said Dr. Kozyrskyj. "Exposure to germs is lower in the absence of a dog. The administration of an antibiotic may further reduce this exposure and increase the likelihood of asthma development."

"Antibiotics are frequently prescribed for young children for both respiratory and nonrespiratory infections," said Mark J. Rosen, MD, FCCP, President of the American College of Chest Physicians. "Understanding the relationship between antibiotic use and asthma can help clinicians make more informed decisions about treatment options for children."


Story Source:

The above story is based on materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


Cite This Page:

American College of Chest Physicians. "Antibiotic Use In Infants Linked To Asthma." ScienceDaily. ScienceDaily, 12 June 2007. <www.sciencedaily.com/releases/2007/06/070611185240.htm>.
American College of Chest Physicians. (2007, June 12). Antibiotic Use In Infants Linked To Asthma. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/06/070611185240.htm
American College of Chest Physicians. "Antibiotic Use In Infants Linked To Asthma." ScienceDaily. www.sciencedaily.com/releases/2007/06/070611185240.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins