Featured Research

from universities, journals, and other organizations

Poor Performance Of Commercial Antibody Tests For TB

Date:
June 13, 2007
Source:
Public Library of Science
Summary:
Blood-based antibody detection tests for tuberculosis (TB) have come under the spotlight in a research article published in PLoS Medicine. The authors, based in North America and Europe, conducted a "systematic review and meta-analysis" of studies that have been conducted on the accuracy of the tests, and have concluded that they do not perform well in comparison to standard methods. Many of the studies have been poorly conducted, and there is a lack of information on how the tests perform with children and people who are infected with HIV.

Commercial antibody tests for TB produce inconsistent estimates of accuracy, and have no role in the diagnosis of pulmonary TB
Credit: Image courtesy of Public Library of Science

Blood-based antibody detection tests for tuberculosis (TB) have come under the spotlight in a research article published in PLoS Medicine. The authors, based in North America and Europe, conducted a "systematic review and meta-analysis" of studies that have been conducted on the accuracy of the tests, and have concluded that they do not perform well in comparison to standard methods. Many of the studies have been poorly conducted, and there is a lack of information on how the tests perform with children and people who are infected with HIV.

Related Articles


The standard test for TB (the sputum-smear test) has limitations. It is not particularly good at identifying active TB disease in children or people who are HIV-positive. It is also not very sensitive; in other words many people who have active TB disease may not give a positive reading. Therefore, there is an urgent need to develop and evaluate new tests. These tests would have to be cheap, as the countries with the highest rates of TB are in the developing world.

Many companies have developed tests intended to detect the presence of antibodies against TB in the patient's blood. These tests are now being strongly promoted for use in developing countries. However, the authors of the PLoS Medicine article have concluded that, "...published data on commercial antibody detection tests produce inconsistent estimates of accuracy, and none of the assays performs well enough to replace sputum-smear microscopy. These tests thus have little or no role to play in the diagnosis of pulmonary TB at the present time". (Efforts are under way to develop advanced versions of antibody and antigen detection tests, using new technologies. More research to evaluate these newer tests is needed.)

Citation: Steingart KR, Henry M, Laal S, Hopewell PC, Ramsay A, et al. (2007) Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: A systematic review. PLoS Med 4(6): e202. (http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040202)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Poor Performance Of Commercial Antibody Tests For TB." ScienceDaily. ScienceDaily, 13 June 2007. <www.sciencedaily.com/releases/2007/06/070612075228.htm>.
Public Library of Science. (2007, June 13). Poor Performance Of Commercial Antibody Tests For TB. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/06/070612075228.htm
Public Library of Science. "Poor Performance Of Commercial Antibody Tests For TB." ScienceDaily. www.sciencedaily.com/releases/2007/06/070612075228.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins