Featured Research

from universities, journals, and other organizations

Poor Performance Of Commercial Antibody Tests For TB

Date:
June 13, 2007
Source:
Public Library of Science
Summary:
Blood-based antibody detection tests for tuberculosis (TB) have come under the spotlight in a research article published in PLoS Medicine. The authors, based in North America and Europe, conducted a "systematic review and meta-analysis" of studies that have been conducted on the accuracy of the tests, and have concluded that they do not perform well in comparison to standard methods. Many of the studies have been poorly conducted, and there is a lack of information on how the tests perform with children and people who are infected with HIV.

Commercial antibody tests for TB produce inconsistent estimates of accuracy, and have no role in the diagnosis of pulmonary TB
Credit: Image courtesy of Public Library of Science

Blood-based antibody detection tests for tuberculosis (TB) have come under the spotlight in a research article published in PLoS Medicine. The authors, based in North America and Europe, conducted a "systematic review and meta-analysis" of studies that have been conducted on the accuracy of the tests, and have concluded that they do not perform well in comparison to standard methods. Many of the studies have been poorly conducted, and there is a lack of information on how the tests perform with children and people who are infected with HIV.

Related Articles


The standard test for TB (the sputum-smear test) has limitations. It is not particularly good at identifying active TB disease in children or people who are HIV-positive. It is also not very sensitive; in other words many people who have active TB disease may not give a positive reading. Therefore, there is an urgent need to develop and evaluate new tests. These tests would have to be cheap, as the countries with the highest rates of TB are in the developing world.

Many companies have developed tests intended to detect the presence of antibodies against TB in the patient's blood. These tests are now being strongly promoted for use in developing countries. However, the authors of the PLoS Medicine article have concluded that, "...published data on commercial antibody detection tests produce inconsistent estimates of accuracy, and none of the assays performs well enough to replace sputum-smear microscopy. These tests thus have little or no role to play in the diagnosis of pulmonary TB at the present time". (Efforts are under way to develop advanced versions of antibody and antigen detection tests, using new technologies. More research to evaluate these newer tests is needed.)

Citation: Steingart KR, Henry M, Laal S, Hopewell PC, Ramsay A, et al. (2007) Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: A systematic review. PLoS Med 4(6): e202. (http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040202)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Poor Performance Of Commercial Antibody Tests For TB." ScienceDaily. ScienceDaily, 13 June 2007. <www.sciencedaily.com/releases/2007/06/070612075228.htm>.
Public Library of Science. (2007, June 13). Poor Performance Of Commercial Antibody Tests For TB. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2007/06/070612075228.htm
Public Library of Science. "Poor Performance Of Commercial Antibody Tests For TB." ScienceDaily. www.sciencedaily.com/releases/2007/06/070612075228.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins