Featured Research

from universities, journals, and other organizations

New Insights Into Enzyme That Enables Avian Flu Virus To Spread

Date:
June 19, 2007
Source:
American Chemical Society
Summary:
Amid heightened concern over a possible epidemic of bird flu in humans, scientists are reporting critical new insights into the architecture of a key enzyme in the H5N1 avian influenza virus that enables the virus to spread.

Amid heightened concern over a possible epidemic of bird flu in humans, scientists in the United States and Taiwan are reporting critical new insights into the architecture of a key enzyme in the H5N1 avian influenza virus that enables the virus to spread.

Related Articles


Rommie E. Amaro and colleagues focused on what has been termed the "hot pocket," or more technically "the 150-loop." This chain of amino acids forms a cavity in the neuraminidase enzyme that facilitates H5N1's spread. Anti-flu drugs called neuraminidase inhibitors work by entering and binding to the hot pocket, almost like a hand fitting into a glove.

In the new study, researchers report that the hot pocket actually can have internal shapes substantially different than previously believed. That new structural understanding of the 150-loop could be valuable in efforts to design new and more effective anti-flu drugs, they state. Drugs capable of fitting more snugly into the cavity could yield a class of neuraminidase inhibitors that are more effective against H5N1-like flu viruses.

The report is scheduled for the June 20 issue of the Journal of the American Chemical Society. The title of the article is "Remarkable Loop Flexibility in Avian Influenza N1 and Its Implications for Antiviral Drug Design."


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "New Insights Into Enzyme That Enables Avian Flu Virus To Spread." ScienceDaily. ScienceDaily, 19 June 2007. <www.sciencedaily.com/releases/2007/06/070618130937.htm>.
American Chemical Society. (2007, June 19). New Insights Into Enzyme That Enables Avian Flu Virus To Spread. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2007/06/070618130937.htm
American Chemical Society. "New Insights Into Enzyme That Enables Avian Flu Virus To Spread." ScienceDaily. www.sciencedaily.com/releases/2007/06/070618130937.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins