Featured Research

from universities, journals, and other organizations

In Silico Cell For TB Drug Discovery

Date:
June 25, 2007
Source:
University Of Surrey
Summary:
Researchers have completed the first genome-scale model of the microbe that causes tuberculosis. The model may be a highly useful tool to identify new drug targets and design new vaccines. Tuberculosis remains one of the biggest killers in the world today being responsible for nearly ten million cases and one and a half million deaths each year.

A team of researchers from the University of Surrey have completed the first genome-scale model of the microbe that causes tuberculosis. The model may be a highly useful tool to identify new drug targets and design new vaccines.

Tuberculosis remains one of the biggest killers in the world today being responsible for nearly ten million cases and one and a half million deaths each year. New strains are emerging that are resistant to all current front-line anti-tuberculous drugs so new drugs are urgently needed. However, little is known about the metabolism of the TB bacillus and, because of its slow growth, experiments take a very long time.

The Surrey group hopes to speed up the drug discovery process by building an in silico model of the agent that causes TB: a virtual TB bacillus. This model was constructed using information from the entire genome sequence of the pathogen and uses mathematical equations to model the flow of nutrients through the cell. The model is extremely complex, handling 848 different biochemical reactions and 726 genes.

The Surrey team showed that the model successfully simulates many of the peculiar properties of the TB bacillus and identifies the drug targets of known anti-tuberculous drugs. But unlike the biological organisms, the in silico TB bacillus grows in nanoseconds so experiments that would normally take months can be performed in minutes. The group hope that the in silico model may be used to identify new drug targets, particularly those capable of killing persistent bacilli.

The work is published in the high-profile journal Genome Biology and describes not only the model but, for the first time, makes an in silico model available to other researchers via an interactive website. Researchers will be able to perform experiments on the virtual TB bacillus from a beach in Bombay or a mountaintop in Malawi. It is hoped that the availability of this novel research tool will stimulate new approaches to control of this deadly pathogen.


Story Source:

The above story is based on materials provided by University Of Surrey. Note: Materials may be edited for content and length.


Cite This Page:

University Of Surrey. "In Silico Cell For TB Drug Discovery." ScienceDaily. ScienceDaily, 25 June 2007. <www.sciencedaily.com/releases/2007/06/070624135714.htm>.
University Of Surrey. (2007, June 25). In Silico Cell For TB Drug Discovery. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2007/06/070624135714.htm
University Of Surrey. "In Silico Cell For TB Drug Discovery." ScienceDaily. www.sciencedaily.com/releases/2007/06/070624135714.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins