Featured Research

from universities, journals, and other organizations

In Silico Cell For TB Drug Discovery

Date:
June 25, 2007
Source:
University Of Surrey
Summary:
Researchers have completed the first genome-scale model of the microbe that causes tuberculosis. The model may be a highly useful tool to identify new drug targets and design new vaccines. Tuberculosis remains one of the biggest killers in the world today being responsible for nearly ten million cases and one and a half million deaths each year.

A team of researchers from the University of Surrey have completed the first genome-scale model of the microbe that causes tuberculosis. The model may be a highly useful tool to identify new drug targets and design new vaccines.

Related Articles


Tuberculosis remains one of the biggest killers in the world today being responsible for nearly ten million cases and one and a half million deaths each year. New strains are emerging that are resistant to all current front-line anti-tuberculous drugs so new drugs are urgently needed. However, little is known about the metabolism of the TB bacillus and, because of its slow growth, experiments take a very long time.

The Surrey group hopes to speed up the drug discovery process by building an in silico model of the agent that causes TB: a virtual TB bacillus. This model was constructed using information from the entire genome sequence of the pathogen and uses mathematical equations to model the flow of nutrients through the cell. The model is extremely complex, handling 848 different biochemical reactions and 726 genes.

The Surrey team showed that the model successfully simulates many of the peculiar properties of the TB bacillus and identifies the drug targets of known anti-tuberculous drugs. But unlike the biological organisms, the in silico TB bacillus grows in nanoseconds so experiments that would normally take months can be performed in minutes. The group hope that the in silico model may be used to identify new drug targets, particularly those capable of killing persistent bacilli.

The work is published in the high-profile journal Genome Biology and describes not only the model but, for the first time, makes an in silico model available to other researchers via an interactive website. Researchers will be able to perform experiments on the virtual TB bacillus from a beach in Bombay or a mountaintop in Malawi. It is hoped that the availability of this novel research tool will stimulate new approaches to control of this deadly pathogen.


Story Source:

The above story is based on materials provided by University Of Surrey. Note: Materials may be edited for content and length.


Cite This Page:

University Of Surrey. "In Silico Cell For TB Drug Discovery." ScienceDaily. ScienceDaily, 25 June 2007. <www.sciencedaily.com/releases/2007/06/070624135714.htm>.
University Of Surrey. (2007, June 25). In Silico Cell For TB Drug Discovery. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2007/06/070624135714.htm
University Of Surrey. "In Silico Cell For TB Drug Discovery." ScienceDaily. www.sciencedaily.com/releases/2007/06/070624135714.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins