Featured Research

from universities, journals, and other organizations

Antibodies Protect Mice From Developing Respiratory Tularemia

Date:
June 28, 2007
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
A research team led by Dennis W. Metzger, Ph.D., at the Albany Medical College in New York has now shown that treating laboratory mice with a serum containing tularemia-specific antibodies protects the mice against F. tularensis, not only if given before exposure to lethal doses of inhalational F. tularensis but also up to 48 hours after exposure. These findings suggest a possible alternative treatment approach to traditional antibiotics.

The respiratory form of tularemia, a potentially serious bacterial disease, is a significant public health concern because it is highly infectious, it has a high mortality rate if untreated, and it could be introduced into a population in an intentional act of bioterror. Though much research is focused on developing drugs and vaccines targeted to the bacterium that causes tularemia, Francisella tularensis, little is known about the role that antibodies play in protecting against infection.

A research team led by Dennis W. Metzger, Ph.D., at the Albany Medical College in New York has now shown that treating laboratory mice with a serum containing tularemia-specific antibodies protects the mice against F. tularensis, not only if given before exposure to lethal doses of inhalational F. tularensis but also up to 48 hours after exposure. These findings suggest a possible alternative treatment approach to traditional antibiotics.

In the absence of a licensed vaccine, such an approach might prove especially useful early on in the case of an intentional act of bioterrorism. The tularemia-specific antibodies may enhance an individual's immune responses to the bacteria after exposure, in essence acting as a surrogate vaccine. Other advantages of this approach over conventional methods of treatment include the fact that it is rapid and specific; it could be used in people with weakened immune systems; and it minimizes the chances of contributing to treatment-resistant bacteria.

Funding for Dr. Metzger's research was provided by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

Citation: "Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis," by GS Kirimanjeswara et al. The Journal of Immunology 179:532-539 (2007).


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Antibodies Protect Mice From Developing Respiratory Tularemia." ScienceDaily. ScienceDaily, 28 June 2007. <www.sciencedaily.com/releases/2007/06/070627110613.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2007, June 28). Antibodies Protect Mice From Developing Respiratory Tularemia. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2007/06/070627110613.htm
NIH/National Institute of Allergy and Infectious Diseases. "Antibodies Protect Mice From Developing Respiratory Tularemia." ScienceDaily. www.sciencedaily.com/releases/2007/06/070627110613.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins