Featured Research

from universities, journals, and other organizations

Small Molecules May Explain Psoriasis

Date:
July 12, 2007
Source:
Karolinska Institutet
Summary:
MicroRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema.

A research team at the Swedish medical university Karolinska Institutet has shown for the time that microRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema. The research team is led by Professor Mona Ståhle.

Related Articles


MicroRNA are small RNA molecules that regulate gene expression, and by acting on many different proteins and different cellular mechanisms in skin and immune cells these small RNA molecules may be an important factor in the development of disease. Therapies based on microRNA might therefore in the future become more effective than medicines targeted at individual proteins.

"We believe that microRNA may also be significant in regulating other common chronic inflammatory diseases such as arthritis and certain autoimmune diseases," says Andor Pivarcsi, who has directed the study together with Enikö Sonkoly.

The study shows that microRNA has different patterns of expression in psoriasis compared with normal skin and also in comparison with atopic eczema. One of these molecules, miR-203, is of particular interest as it is greatly upregulated in psoriasis and is only expressed by the skin's epithelial cells, keratinocytes.

No one has previously investigated whether this quite recently discovered group of molecules might be significant in inflammatory diseases. Psoriasis and atopic eczema are the most common chronic inflammatory skin diseases. Despite intensive research, not enough is yet known about underlying disease mechanisms, which hampers the development of effective drugs.

Reference:  "MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?"  PLoS ONE, 11 July 2007


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Small Molecules May Explain Psoriasis." ScienceDaily. ScienceDaily, 12 July 2007. <www.sciencedaily.com/releases/2007/07/070711105622.htm>.
Karolinska Institutet. (2007, July 12). Small Molecules May Explain Psoriasis. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2007/07/070711105622.htm
Karolinska Institutet. "Small Molecules May Explain Psoriasis." ScienceDaily. www.sciencedaily.com/releases/2007/07/070711105622.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins