Featured Research

from universities, journals, and other organizations

Small Molecules May Explain Psoriasis

Date:
July 12, 2007
Source:
Karolinska Institutet
Summary:
MicroRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema.

A research team at the Swedish medical university Karolinska Institutet has shown for the time that microRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema. The research team is led by Professor Mona Stεhle.

MicroRNA are small RNA molecules that regulate gene expression, and by acting on many different proteins and different cellular mechanisms in skin and immune cells these small RNA molecules may be an important factor in the development of disease. Therapies based on microRNA might therefore in the future become more effective than medicines targeted at individual proteins.

"We believe that microRNA may also be significant in regulating other common chronic inflammatory diseases such as arthritis and certain autoimmune diseases," says Andor Pivarcsi, who has directed the study together with Enikφ Sonkoly.

The study shows that microRNA has different patterns of expression in psoriasis compared with normal skin and also in comparison with atopic eczema. One of these molecules, miR-203, is of particular interest as it is greatly upregulated in psoriasis and is only expressed by the skin's epithelial cells, keratinocytes.

No one has previously investigated whether this quite recently discovered group of molecules might be significant in inflammatory diseases. Psoriasis and atopic eczema are the most common chronic inflammatory skin diseases. Despite intensive research, not enough is yet known about underlying disease mechanisms, which hampers the development of effective drugs.

Reference:  "MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?"  PLoS ONE, 11 July 2007


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Small Molecules May Explain Psoriasis." ScienceDaily. ScienceDaily, 12 July 2007. <www.sciencedaily.com/releases/2007/07/070711105622.htm>.
Karolinska Institutet. (2007, July 12). Small Molecules May Explain Psoriasis. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2007/07/070711105622.htm
Karolinska Institutet. "Small Molecules May Explain Psoriasis." ScienceDaily. www.sciencedaily.com/releases/2007/07/070711105622.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) — Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins