Featured Research

from universities, journals, and other organizations

Rat Study Describes Brain Region Connected To Declarative Memory

Date:
July 18, 2007
Source:
Universitat Autonoma de Barcelona
Summary:
Research with experimental rats carried out by the Institute of Neuroscience of the UAB describes the brain region connected to how our declarative memory functions. According to this experiment, part of the prefrontal cortex plays a key role in the social transmission of food preference. Results from the research could be useful to find new treatment for diseases that affect the memory, such as Alzheimer's disease.

Research with experimental rats carried out by the Institute of Neuroscience of the UAB describes the brain region connected to how our declarative memory functions. According to this experiment, part of the prefrontal cortex plays a key role in the social transmission of food preference. Results from the research could be useful to find new treatment for diseases that affect the memory, such as Alzheimer's disease.

Declarative memory is described as a flexible, conscience and associative type of memory (i.e., it is based on relations between different stimuli). It differs from other types of memories that allow us to recall effective or emotionally-charged data, or carry out processes such as riding a bicycle or playing an instrument. Declarative memory allows us to remember things such as specific moments of our lives, names of people, what we ate for lunch, the capitals of the world, etc. The malfunctioning of this type of memory is one of the most common symptoms found in those suffering from Alzheimer's disease.

A useful model from which to learn about how declarative memory functions is the social transmission of food preference. In other species, this task is connected to the survival of the species and plays a crucial role in their evolution. In this research, the social transmission of food preference was carried out with experimental rats.

When one rodent sniffs another rodent's snout right after the second one has eaten, the first one will later choose to eat the same exact food. Animals learn to remember what their congeners eat and, in that way, lower the risk of eating new foods that could be harmful to them. In addition, they must later use this information acquired during a brief episode of social interaction in very different circumstances. Therefore, they need the flexible expression of memory, which is one of the main traits of declarative memory.

This task depends on learning how to associate smells, a function that is commanded by a specific region of the brain, the nucleus basalis magnocellularis (NBM), which produces acetylcholine (a neurotransmitter that "transfers information" from one neurone to another through synapses). This chemical substance is essential in making the memory work correctly. The nucleus basalis magnocellularis equivalent in humans is the nucleus basalis Meynert. Precisely this is one of the regions of the brain that shown signs of degeneration among those who suffer from Alzheimer's (and who are often treated with drugs that help to produce acetylcholine).

The acetylcholine produced by the nucleus basalis is transferred to other regions of the brain, where it is "recognised" by receptor molecules. The research team examined the possibility of one part of the brain, the prelimbic prefrontal cortex, being linked to the social transmission of food preference. To do so, they applied a chemical compound to the experimental rats that neutralised the acetylcholine receptors (muscarinic cholinergic receptor) of this region. By blocking the receptor, the effect of the neurotransmitter was also neutralised and the changes in the animals' behaviour were observed.

The results demonstrated that the social transmission of food preference was clearly affected after neutralising the acetylcholine receptors. Researchers also verified that the effects were not due to other aspects that could alter the experiment, such as lack of olfactory perception, motivation or social interaction. The results therefore suggest that the prelimbic prefrontal cortex, via the use of acetylcholine, regulates cognitive operations (e.g. flexibility in behaviour, attention or strategic planning) that could be needed to correctly express social transmission of food preference, and therefore necessary for our declarative memory.


Story Source:

The above story is based on materials provided by Universitat Autonoma de Barcelona. Note: Materials may be edited for content and length.


Cite This Page:

Universitat Autonoma de Barcelona. "Rat Study Describes Brain Region Connected To Declarative Memory." ScienceDaily. ScienceDaily, 18 July 2007. <www.sciencedaily.com/releases/2007/07/070718002044.htm>.
Universitat Autonoma de Barcelona. (2007, July 18). Rat Study Describes Brain Region Connected To Declarative Memory. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2007/07/070718002044.htm
Universitat Autonoma de Barcelona. "Rat Study Describes Brain Region Connected To Declarative Memory." ScienceDaily. www.sciencedaily.com/releases/2007/07/070718002044.htm (accessed September 23, 2014).

Share This



More Mind & Brain News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins