Featured Research

from universities, journals, and other organizations

Early Warning For Acute Kidney Injury

Date:
August 3, 2007
Source:
BioMed Central
Summary:
Clinicians currently lack advance warning of acute kidney injury for patients where kidney injury timing is unknown. Now pediatric research has identified a potential biomarker to predict acute kidney injury earlier than current tests, opening a vital window for prevention of this life-threatening condition.

Clinicians currently lack advance warning of acute kidney injury (AKI) for patients where kidney injury timing is unknown. Now paediatric research published in the open access journal, Critical Care, has identified a potential biomarker to predict AKI earlier than current tests, opening a vital window for prevention of this life-threatening condition.

A US team led by Michael Zappitelli, Kimberly Washburn and Stuart Goldstein from Baylor College of Medicine/Texas Children's Hospital in Houston studied urinary neutrophil gelatinase associated lipocalin (uNGAL) levels in a prospective cohort of 140 critically ill children. They found that uNGAL was a good diagnostic marker for AKI development, with levels at least 6 times higher than control subjects.

The rise in uNGAL concentration occurred 48 hours before a jump in serum creatinine (SCr) levels. This is significant because SCr, currently the main AKI biomarker used in clinical settings, shows a reduction in renal function has already begun and even small SCr rises are independently associated with mortality.

The authors suggest that uNGAL is a good diagnostic marker for early prediction of AKI when the timing of the kidney injury is unknown. However, they caution that urinary NGAL may not be a good predictor of AKI severity after a jump in SCr has occurred.

The authors found that children in the study with sepsis have higher uNGAL concentrations than those without sepsis, but the relationship between uNGAL and AKI was maintained. "The ultimate goal will be to have a biomarker panel in a urine dipstick format to rapidly assess biomarker threshold concentrations," Zappitelli says. It remains to be seen whether the results will be duplicated in adults, in whom a higher degree of chronic inflammation may also affect uNGAL levels.

Article: "Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study" Michael Zappitelli, Kimberly K Washburn, Ayse A Arikan, Laura Loftis, Qing Ma, Prasad Devarajan, Chirag R Parikh and Stuart L Goldstein, Critical Care (in press)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Early Warning For Acute Kidney Injury." ScienceDaily. ScienceDaily, 3 August 2007. <www.sciencedaily.com/releases/2007/08/070802090729.htm>.
BioMed Central. (2007, August 3). Early Warning For Acute Kidney Injury. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2007/08/070802090729.htm
BioMed Central. "Early Warning For Acute Kidney Injury." ScienceDaily. www.sciencedaily.com/releases/2007/08/070802090729.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins