Featured Research

from universities, journals, and other organizations

Hematology: Protein Helps Determine When Red Blood Cells Die

Date:
August 7, 2007
Source:
Journal of Clinical Investigation
Summary:
The accumulation of high levels of oxidants in red blood cells dramatically decreases their lifespan and is associated with anemia. Little was known about the molecular regulation of the response to oxidants in red blood cells, but in a new study the protein FoxO3 is now shown to be required for mouse red blood cells to control their levels of oxidants and it is therefore probable that Fox03 regulates the lifespan of these cells.

The accumulation of high levels of oxidants in red blood cells dramatically decreases their lifespan and is associated with anemia.

Little was known about the molecular regulation of the response to oxidants in red blood cells, but in a study appearing in the August issue of the Journal of Clinical Investigation the protein FoxO3 is now shown to be required for mouse red blood cells to control their levels of oxidants and it is therefore probable that Foxo3 regulates the lifespan of these cells.

In the study, Saghi Ghaffari and colleagues from the Mount Sinai School of Medicine, New York, show that the induction of high levels of oxidants in mice lacking Foxo3 caused them to die rapidly.

Red blood cells from these mice expressed fewer proteins able to scavenge the oxidants and had a shorter lifespan than red blood cells from normal mice. Importantly, treatment of the cells with an antioxidant increased the lifespan of the red blood cells lacking Fox03.

A lack of Foxo3, and therefore high levels of oxidants, also decreased the rate of red blood cell development and led the authors to posit that it might be possible to exploit these functions of Fox03 to increase the lifespan and rate of development of red blood cells.

However, as Harvey Lodish, from the Whitehead Institute for Biomedical Research, notes in his accompanying commentary these data highlight "the importance of determining both the direct targets of Fox03 and its own regulation in helping us understand how a red blood cell lacking a nucleus knows exactly when to die."

Article: FoxO3 is required for the regulation of oxidative stress in erythropoiesis


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Hematology: Protein Helps Determine When Red Blood Cells Die." ScienceDaily. ScienceDaily, 7 August 2007. <www.sciencedaily.com/releases/2007/08/070802182116.htm>.
Journal of Clinical Investigation. (2007, August 7). Hematology: Protein Helps Determine When Red Blood Cells Die. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2007/08/070802182116.htm
Journal of Clinical Investigation. "Hematology: Protein Helps Determine When Red Blood Cells Die." ScienceDaily. www.sciencedaily.com/releases/2007/08/070802182116.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins