Featured Research

from universities, journals, and other organizations

Metabolic Disease: AMPK Keeps Energy Balance Steady

Date:
August 8, 2007
Source:
Journal of Clinical Investigation
Summary:
The increasing number of individuals with obesity and diabetes has made understanding the regulation of food intake and energy balance a focus of many researchers. One aspect of such research is understanding how the brain controls these processes. Expression of the protein AMPK in neurons in the brain has been suggested to be important for regulating energy balance, but in which neurons its expression is important was not clear.

The increasing number of individuals with obesity and diabetes has made understanding the regulation of food intake and energy balance a focus of many researchers.

Related Articles


One aspect of such research is understanding how the brain controls these processes. Expression of the protein AMPK in neurons in the brain has been suggested to be important for regulating energy balance, but in which neurons its expression is important was not clear.

To address this issue, Dominic Withers and colleagues from University College London, United Kingdom, generated mice lacking AMPK function in either POMC neurons or AgRP neurons. As reported in the August issue of the Journal of Clinical Investigation mice lacking AMPK function in POMC neurons became obese because they reduced their energy expenditure and increased their food intake after fasting.

By contrast, mice lacking AMPK function in AgRP neurons showed age-dependent decrease in body weight. Surprisingly, these effects were mediated by an inability of the neurons to respond to changes in glucose levels and not caused by impaired responses to the hormone regulators of energy balance leptin and insulin. These latter observations, that AMPK is only required for the response of POMC and AgRP neurons to some signals that regulate energy balance led the authors to conclude that AMPK is "not a general sensor and integrator of energy homeostasis in the hypothalamus."

The surprising nature of the results is discussed further in an accompanying commentary by Joel Elmquist from the University of Texas Southwestern. Elmquist notes that it is complex studies such as these that uncover unexpected results that are "needed to combat the growing problems that are obesity and diabetes."

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Metabolic Disease: AMPK Keeps Energy Balance Steady." ScienceDaily. ScienceDaily, 8 August 2007. <www.sciencedaily.com/releases/2007/08/070802210723.htm>.
Journal of Clinical Investigation. (2007, August 8). Metabolic Disease: AMPK Keeps Energy Balance Steady. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2007/08/070802210723.htm
Journal of Clinical Investigation. "Metabolic Disease: AMPK Keeps Energy Balance Steady." ScienceDaily. www.sciencedaily.com/releases/2007/08/070802210723.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins