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Math Model For Circadian Rhythm Created

Date:
August 30, 2007
Source:
Cornell University
Summary:
The internal clock in living beings that regulates sleeping and waking patterns -- usually called the circadian clock -- has often befuddled scientists due to its mysterious time delays. Molecular interactions that regulate the circadian clock happen within milliseconds, yet the body clock resets about every 24 hours. What, then, stretches the expression of the clock over such a relatively long period? Researchers hypothesize that the accepted model of circadian rhythmicity may be missing a key link, based on a mathematical model of what happens during the sleeping/waking cycle in fruit flies.

A graphic representation of the molecular interactions of circadian rhythm, based on work recently published by Cornell researchers. They proposed that a new, unknown molecule, called the focus-binding mediator (FBM) would need to be inserted into the cycle along with proteins period and timeless, in order for mathematical modeling of the system to make sense.
Credit: Image courtesy of Cornell University

The internal clock in living beings that regulates sleeping and waking patterns -- usually called the circadian clock -- has often befuddled scientists due to its mysterious time delays. Molecular interactions that regulate the circadian clock happen within milliseconds, yet the body clock resets about every 24 hours. What, then, stretches the expression of the clock over such a relatively long period?

Cornell researchers have contributed to the answer, thanks to new mathematical models recently published.

In the August online edition of Public Library of Science (PLOS) Computational Biology, Cornell biomolecular engineer Kelvin Lee, in collaboration with graduate student Robert S. Kuczenski, Kevin C. Hong '05 and Jordi Garcia-Ojalvo of Universitat Politecnica de Catalunya, Spain, hypothesize that the accepted model of circadian rhythmicity may be missing a key link, based on a mathematical model of what happens during the sleeping/waking cycle in fruit flies.

"We didn't discover any new proteins or genes," Lee said. "We took all the existing knowledge, and we tried to organize it."

Using mathematical models initially created by Hong, who has since graduated, the team set out to map the molecular interactions of proteins called period and timeless -- widely known to be related to the circadian clock.

The group hypothesized that an extra, unknown protein would need to be inserted into the cycle with period and timeless, a molecule that Kuczenski named the focus-binding mediator, in order for the cycle to stretch to 24 hours.

Lee said many scientists are interested in studying the circadian clock, and not just to understand such concepts as jet lag -- fatigue induced by traveling across time zones. Understanding the body's biological cycle might, for example, lead to better timing of delivering chemotherapy, when the body would be most receptive, Lee said.


Story Source:

The above story is based on materials provided by Cornell University. Note: Materials may be edited for content and length.


Cite This Page:

Cornell University. "Math Model For Circadian Rhythm Created." ScienceDaily. ScienceDaily, 30 August 2007. <www.sciencedaily.com/releases/2007/08/070827174303.htm>.
Cornell University. (2007, August 30). Math Model For Circadian Rhythm Created. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2007/08/070827174303.htm
Cornell University. "Math Model For Circadian Rhythm Created." ScienceDaily. www.sciencedaily.com/releases/2007/08/070827174303.htm (accessed October 23, 2014).

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