Featured Research

from universities, journals, and other organizations

Math Model For Circadian Rhythm Created

Date:
August 30, 2007
Source:
Cornell University
Summary:
The internal clock in living beings that regulates sleeping and waking patterns -- usually called the circadian clock -- has often befuddled scientists due to its mysterious time delays. Molecular interactions that regulate the circadian clock happen within milliseconds, yet the body clock resets about every 24 hours. What, then, stretches the expression of the clock over such a relatively long period? Researchers hypothesize that the accepted model of circadian rhythmicity may be missing a key link, based on a mathematical model of what happens during the sleeping/waking cycle in fruit flies.

A graphic representation of the molecular interactions of circadian rhythm, based on work recently published by Cornell researchers. They proposed that a new, unknown molecule, called the focus-binding mediator (FBM) would need to be inserted into the cycle along with proteins period and timeless, in order for mathematical modeling of the system to make sense.
Credit: Image courtesy of Cornell University

The internal clock in living beings that regulates sleeping and waking patterns -- usually called the circadian clock -- has often befuddled scientists due to its mysterious time delays. Molecular interactions that regulate the circadian clock happen within milliseconds, yet the body clock resets about every 24 hours. What, then, stretches the expression of the clock over such a relatively long period?

Cornell researchers have contributed to the answer, thanks to new mathematical models recently published.

In the August online edition of Public Library of Science (PLOS) Computational Biology, Cornell biomolecular engineer Kelvin Lee, in collaboration with graduate student Robert S. Kuczenski, Kevin C. Hong '05 and Jordi Garcia-Ojalvo of Universitat Politecnica de Catalunya, Spain, hypothesize that the accepted model of circadian rhythmicity may be missing a key link, based on a mathematical model of what happens during the sleeping/waking cycle in fruit flies.

"We didn't discover any new proteins or genes," Lee said. "We took all the existing knowledge, and we tried to organize it."

Using mathematical models initially created by Hong, who has since graduated, the team set out to map the molecular interactions of proteins called period and timeless -- widely known to be related to the circadian clock.

The group hypothesized that an extra, unknown protein would need to be inserted into the cycle with period and timeless, a molecule that Kuczenski named the focus-binding mediator, in order for the cycle to stretch to 24 hours.

Lee said many scientists are interested in studying the circadian clock, and not just to understand such concepts as jet lag -- fatigue induced by traveling across time zones. Understanding the body's biological cycle might, for example, lead to better timing of delivering chemotherapy, when the body would be most receptive, Lee said.


Story Source:

The above story is based on materials provided by Cornell University. Note: Materials may be edited for content and length.


Cite This Page:

Cornell University. "Math Model For Circadian Rhythm Created." ScienceDaily. ScienceDaily, 30 August 2007. <www.sciencedaily.com/releases/2007/08/070827174303.htm>.
Cornell University. (2007, August 30). Math Model For Circadian Rhythm Created. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2007/08/070827174303.htm
Cornell University. "Math Model For Circadian Rhythm Created." ScienceDaily. www.sciencedaily.com/releases/2007/08/070827174303.htm (accessed September 30, 2014).

Share This



More Computers & Math News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Apple Releases 'Shellshock' Fix Despite Few Affected Users

Apple Releases 'Shellshock' Fix Despite Few Affected Users

Newsy (Sep. 29, 2014) Apple released a security fix for the "Shellshock" vulnerability Monday, though it says only "advanced UNIX users" of OS X need it. Video provided by Newsy
Powered by NewsLook.com
Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
New Facebook Ad Platform Goes Where You Go On The Web

New Facebook Ad Platform Goes Where You Go On The Web

Newsy (Sep. 29, 2014) Called Atlas, the platform allows advertisers to place ads based on Facebook info on sites outside of Facebook. Video provided by Newsy
Powered by NewsLook.com
Google Tightens Requirements For Android Manufacturers

Google Tightens Requirements For Android Manufacturers

Newsy (Sep. 27, 2014) Phonemakers who want to use Google’s software in their devices will have to stick to more stringent requirements. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins