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Specific H. Pylori Strains Are Associated With Precancerous Lesions

Date:
August 30, 2007
Source:
Journal of the National Cancer Institute
Summary:
A new study suggests that previous estimates of the risk of gastric cancer following infection with the bacterium Helicobacter pylori may be too low. The research identifies certain strains of the bacterium associated with precancerous gastric lesions. H. pylori live in the human stomach. But many people with H. pylori infections never develop gastric cancer. Some evidence suggests that genetic variation among different strains of the bacteria may explain why some infections result in gastric cancer while others do not.
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A new study suggests that previous estimates of the risk of gastric cancer following infection with the bacterium Helicobacter pylori may be too low. The research identifies certain strains of the bacterium associated with precancerous gastric lesions.

H. pylori live in the human stomach. But many people with H. pylori infections never develop gastric cancer. Some evidence suggests that genetic variation among different strains of the bacteria may explain why some infections result in gastric cancer while others do not.

Martyn Plummer of the International Agency for Research on Cancer in Lyon, France, and colleagues examined the relationship between several strains of H. pylori and the development of gastric cancer. They analyzed gastric biopsy specimens from 2,145 participants in a chemoprevention trial in Venezuela.

The researchers found a strong association between precancerous gastric lesions and infection with particular strains of H. pylori. "Our study adds to the emerging body of evidence that the strength of the association between H. pylori and gastric [cancer] has been underestimated. In a recent review of infection-related cancer, the proportion of all gastric cancers worldwide attributed to H. pylori was estimated to be 63%. Our results imply that, in populations with a high prevalence of [disease-causing] H. pylori, the attributable fraction may be even higher," the authors write.

This research was recently published in the Journal of the National Cancer Institute.


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The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


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Journal of the National Cancer Institute. "Specific H. Pylori Strains Are Associated With Precancerous Lesions." ScienceDaily. ScienceDaily, 30 August 2007. <www.sciencedaily.com/releases/2007/08/070828180436.htm>.
Journal of the National Cancer Institute. (2007, August 30). Specific H. Pylori Strains Are Associated With Precancerous Lesions. ScienceDaily. Retrieved May 25, 2015 from www.sciencedaily.com/releases/2007/08/070828180436.htm
Journal of the National Cancer Institute. "Specific H. Pylori Strains Are Associated With Precancerous Lesions." ScienceDaily. www.sciencedaily.com/releases/2007/08/070828180436.htm (accessed May 25, 2015).

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