Featured Research

from universities, journals, and other organizations

Aluminum In Breast Tissue: A Possible Factor In The Cause Of Breast Cancer

Date:
September 2, 2007
Source:
Keele University
Summary:
A new study has identified a regionally-specific distribution of aluminum in breast tissue which may have implications for the cause of breast cancer. Scientists have found that the aluminum content of breast tissue and breast tissue fat was significantly higher in the outer regions of the breast, in close proximity to the area where there would be the highest density of antiperspirant.

A new study has identified a regionally-specific distribution of aluminium in breast tissue which may have implications for the cause of breast cancer.

Scientists have found that the aluminium content of breast tissue and breast tissue fat was significantly higher in the outer regions of the breast, in close proximity to the area where there would be the highest density of antiperspirant.

Recent research has linked breast cancer with the use of aluminium-based, underarm antiperspirants. The known, but unaccounted for, higher incidence of tumours in the upper outer quadrant of the breast seemed to support such a contention. However, the identification of a mechanism of antiperspirant-induced breast cancer has remained elusive.

A team, led by Dr Chris Exley of the Birchall Centre for Inorganic Chemistry and Materials at Keele University in the UK, measured the aluminium content of breast tissue from 17 breast cancer patients recruited from Wythenshaw Hospital, Manchester, UK. Whether differences in the distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained.

The major constituent of antiperspirant is aluminium salts which have long been associated with cancer, as well as other human disease. The daily application of aluminium-based antiperspirants should result in the presence of aluminium in the tissue of the underarm and surrounding areas, though there is almost no data on aluminium in breast tissue.

Breast cancer is the most common malignancy in women and is the leading cause of death among women aged 35-54. The cause of breast cancer is unknown and is likely to be a combination of generic and environmental factors.

Each of the patients in the study had undergone a mastectomy and biopsies from four different regions of the breast on a transect from the outer (axilla and lateral) to the inner (middle and medial) breast were collected.

Tests showed that while there were significant differences in the concentrations of aluminium between individuals they did show “a statistically higher concentration of aluminium in the outer as compared with the inner region of the breast”.

The report, published in the Journal of Inorganic Biochemistry, goes on: “We have confirmed the presence of aluminium in breast tissue and its possible regional distribution within the breast. Higher content of aluminium in the outer breast might be explained by this region’s closer proximity to the underarm where the highest density of application of antiperspirant could be assumed. There is evidence that skin is permeable to aluminium when applied as antiperspirant.

“However, we have no direct evidence that the aluminium measured in these breast biopsies originated from antiperspirant. An alternative explanation might be that tumourous tissue acts as a ‘sink’ for systemic aluminium”.

But it goes on to say that “aluminium in breast tissue might contribute” to breast cancer.

“Aluminium is a metalloestrogen, it is genotoxic, is bound by DNA and has been shown to be carcinogenic. It is also a pro-oxidant and this unusual property might provide a mechanistic basis for any putative carcinogenicity. The confirmed presence of aluminium in breast tissue biopsies highlights its potential as a possible factor in the aetiology of breast cancer”.


Story Source:

The above story is based on materials provided by Keele University. Note: Materials may be edited for content and length.


Cite This Page:

Keele University. "Aluminum In Breast Tissue: A Possible Factor In The Cause Of Breast Cancer." ScienceDaily. ScienceDaily, 2 September 2007. <www.sciencedaily.com/releases/2007/08/070831210302.htm>.
Keele University. (2007, September 2). Aluminum In Breast Tissue: A Possible Factor In The Cause Of Breast Cancer. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2007/08/070831210302.htm
Keele University. "Aluminum In Breast Tissue: A Possible Factor In The Cause Of Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/08/070831210302.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins