Featured Research

from universities, journals, and other organizations

Genetic Background To Severe Urinary Tract Infections

Date:
September 10, 2007
Source:
Public Library of Science
Summary:
If you sit on cold boulders or forget to wear your woollen pants, you can develop a urinary tract infection, or so the story goes. It turns out though, that these diseases are more complicated than this, and in some cases they have a genetic background. Scientists have found a gene that appears to lie behind many of the most severe urinary tract infections.

If you sit on cold boulders or forget to wear your woollen underwear, you can develop a urinary tract infection, or so the story goes. It turns out though, that these diseases are more complicated than this, and in some cases they have a genetic background. Scientists at Lund University in Sweden have found a gene that appears to lie behind many of the most severe urinary tract infections.

It is well known that certain people have a tendency to develop urinary tract infections again and again. These infections often start in childhood. In serious cases they can lead to infections of the renal pelvis, which ultimately can damage the kidneys so severely that the patient will need dialysis or a kidney transplant.

Doctors have long been hoping for a method for early detection of the small group of people who are in the risk zone for renal pelvis infections. If they could single them out early, it would be unnecessary to subject all children who get a urinary tract infection to a thorough and sometimes unpleasant examination. Instead, such examinations and any preventative treatment could be reserved for those who really need it.

"Many research teams have long been looking for a genetic background to the disease. We have found a gene that could be used as a risk marker and a method for singling out the susceptible group," says researcher Ann-Charlotte Lundstedt and Professor Catharina Svanborg.

The gene in question produces a protein that is involved in the immune defence system. It regulates the migration of white blood corpuscles to the kidneys and their work with neutralizing infectious bacteria. The Lund team has previously shown that the gene protects against renal pelvis inflammation in animal experiments. Now, in studies of children and adults with recurrent renal pelvis infections, they have also shown that mutations of this very gene are much more common in kidney patients than in healthy control individuals.

"We also saw that even patients without genetic changes have low levels of this protein. Therefore, a combination of a genetic examinations and a protein measurement could be a good way to find those who are most clearly in the risk zone," says Catharina Svanborg.

The study is published on September 5 in the online, open-access journal PLoS One.

Citation: Lundstedt A-C, McCarthy S, Gustafsson MCU, Godaly G, Jodal U, et al (2007) A Genetic Basis of Susceptibility to Acute Pyelonephritis. PLoS ONE 2(9): e825. doi:10.1371/journal.pone.0000825


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Genetic Background To Severe Urinary Tract Infections." ScienceDaily. ScienceDaily, 10 September 2007. <www.sciencedaily.com/releases/2007/09/070904214408.htm>.
Public Library of Science. (2007, September 10). Genetic Background To Severe Urinary Tract Infections. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2007/09/070904214408.htm
Public Library of Science. "Genetic Background To Severe Urinary Tract Infections." ScienceDaily. www.sciencedaily.com/releases/2007/09/070904214408.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins