Featured Research

from universities, journals, and other organizations

Genetic Background To Severe Urinary Tract Infections

Date:
September 10, 2007
Source:
Public Library of Science
Summary:
If you sit on cold boulders or forget to wear your woollen pants, you can develop a urinary tract infection, or so the story goes. It turns out though, that these diseases are more complicated than this, and in some cases they have a genetic background. Scientists have found a gene that appears to lie behind many of the most severe urinary tract infections.

If you sit on cold boulders or forget to wear your woollen underwear, you can develop a urinary tract infection, or so the story goes. It turns out though, that these diseases are more complicated than this, and in some cases they have a genetic background. Scientists at Lund University in Sweden have found a gene that appears to lie behind many of the most severe urinary tract infections.

It is well known that certain people have a tendency to develop urinary tract infections again and again. These infections often start in childhood. In serious cases they can lead to infections of the renal pelvis, which ultimately can damage the kidneys so severely that the patient will need dialysis or a kidney transplant.

Doctors have long been hoping for a method for early detection of the small group of people who are in the risk zone for renal pelvis infections. If they could single them out early, it would be unnecessary to subject all children who get a urinary tract infection to a thorough and sometimes unpleasant examination. Instead, such examinations and any preventative treatment could be reserved for those who really need it.

"Many research teams have long been looking for a genetic background to the disease. We have found a gene that could be used as a risk marker and a method for singling out the susceptible group," says researcher Ann-Charlotte Lundstedt and Professor Catharina Svanborg.

The gene in question produces a protein that is involved in the immune defence system. It regulates the migration of white blood corpuscles to the kidneys and their work with neutralizing infectious bacteria. The Lund team has previously shown that the gene protects against renal pelvis inflammation in animal experiments. Now, in studies of children and adults with recurrent renal pelvis infections, they have also shown that mutations of this very gene are much more common in kidney patients than in healthy control individuals.

"We also saw that even patients without genetic changes have low levels of this protein. Therefore, a combination of a genetic examinations and a protein measurement could be a good way to find those who are most clearly in the risk zone," says Catharina Svanborg.

The study is published on September 5 in the online, open-access journal PLoS One.

Citation: Lundstedt A-C, McCarthy S, Gustafsson MCU, Godaly G, Jodal U, et al (2007) A Genetic Basis of Susceptibility to Acute Pyelonephritis. PLoS ONE 2(9): e825. doi:10.1371/journal.pone.0000825


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Genetic Background To Severe Urinary Tract Infections." ScienceDaily. ScienceDaily, 10 September 2007. <www.sciencedaily.com/releases/2007/09/070904214408.htm>.
Public Library of Science. (2007, September 10). Genetic Background To Severe Urinary Tract Infections. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2007/09/070904214408.htm
Public Library of Science. "Genetic Background To Severe Urinary Tract Infections." ScienceDaily. www.sciencedaily.com/releases/2007/09/070904214408.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins