Featured Research

from universities, journals, and other organizations

New Cause Of Blindness Discovered

Date:
September 10, 2007
Source:
Public Library of Science
Summary:
Scientists found evidence for blindness associated with a gene involved in retinal pH regulation. Their characterization of a mouse model with a targeted disruption of the Slc4a3 gene has revealed a new cause of blindness.

The scientific community is just starting to appreciate the importance of pH regulation in normal vision, according to researchers. Drs Joe Casey and Yves Sauvé found evidence for blindness associated with a gene involved in retinal pH regulation. 

Their characterization of a mouse model with a targeted disruption of the Slc4a3 gene has revealed a new cause of blindness. Identification of Slc4a3 as underlying a previously unrecognized cause of blindness has direct clinical implications: it opens the door to a new diagnostic possibility for many yet unknown causes of blindness, including hereditary vitreoretinal degenerations (HVDs). No link has been established between Slc4a3 and HVDs.

The similarities between the disease of Slc4a3 deficient mice and individuals with HVDs, however, suggest that Slc4a3 null mice represent the first model of these blinding conditions, for which there is no cure.

Their findings thus lead to the conclusion that approaches targeting retinal extracellular pH regulation are worth exploring as treatments for HVDs and perhaps other types of blindness.

Citation: Alvarez BV, Gilmour GS, Mema SC, Martin BT, Shull GE, et al (2007) Blindness Caused by Deficiency in AE3 Chloride/Bicarbonate Exchanger. PLoS One 2(9): e839. doi:10.1371/journal.pone.0000839


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "New Cause Of Blindness Discovered." ScienceDaily. ScienceDaily, 10 September 2007. <www.sciencedaily.com/releases/2007/09/070904214412.htm>.
Public Library of Science. (2007, September 10). New Cause Of Blindness Discovered. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2007/09/070904214412.htm
Public Library of Science. "New Cause Of Blindness Discovered." ScienceDaily. www.sciencedaily.com/releases/2007/09/070904214412.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) — Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) — According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) — The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins