Featured Research

from universities, journals, and other organizations

Metabolic Syndrome Heightens Risk For Development Of Uric-acid Kidney Stones

Date:
September 14, 2007
Source:
UT Southwestern Medical Center
Summary:
Researchers have found that patients suffering from the metabolic syndrome -- a cluster of conditions that increases the risk for heart disease, stroke and diabetes -- also have a propensity to develop highly acidic urine, which increases the risk of developing kidney stones.

Researchers at UT Southwestern Medical Center have found that patients suffering from the metabolic syndrome -- a cluster of conditions that increases the risk for heart disease, stroke and diabetes -- also have a propensity to develop highly acidic urine, which increases the risk of developing kidney stones.

Related Articles


The first study, to demonstrate this relationship independent of age and renal function, appears in the September issue of the Clinical Journal of the American Society of Nephrology.

The metabolic syndrome is characterized by a group of risk factors that include obesity, high blood pressure, diabetes and high cholesterol. The American Heart Association estimates that more than 50 million Americans suffer from the syndrome.

"Our findings suggest that the presence of an increasing number of metabolic syndrome features augments the propensity for uric-acid stone formation," said Dr. Naim Maalouf, assistant professor of internal medicine and the study's lead author.

In previous studies, UT Southwestern researchers have found that people who were overweight or suffered from diabetes had highly acidic urine, which often leads to the development of uric-acid kidney stones.

The current findings indicate that people with the other components leading to the metabolic syndrome also have highly acidic urine.

"The association of highly acidic urine with elevated levels of systolic blood pressure, serum glucose, triglycerides and lower levels of high-density lipoprotein cholesterol -- all features of the metabolic syndrome -- has not been previously reported," Dr. Maalouf said.

In the study, researchers recorded the height, weight and blood pressure of 148 participants who had never developed kidney stones. They also gathered blood and urine samples and tested the blood for features of the metabolic syndrome.

They found that participants with the metabolic syndrome had highly acidic urine, compared to participants without the syndrome, and the correlation was independent of factors already known to influence urine acidity such as age, gender and body weight.

"This is the first time it has been shown that acidic urine, a major cause of uric-acid stone disease, is a part of the metabolic syndrome," said Dr. Khashayar Sakhaee, chief of mineral metabolism at UT Southwestern and senior author of the study. "We also found that the relationship is not driven by body mass alone."

Uric-acid stones are more difficult to diagnose than other types of kidney stones because they don't show up on regular abdominal X-rays, often delaying the diagnosis and leading to the continued growth of a stone.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

UT Southwestern Medical Center. "Metabolic Syndrome Heightens Risk For Development Of Uric-acid Kidney Stones." ScienceDaily. ScienceDaily, 14 September 2007. <www.sciencedaily.com/releases/2007/09/070913081010.htm>.
UT Southwestern Medical Center. (2007, September 14). Metabolic Syndrome Heightens Risk For Development Of Uric-acid Kidney Stones. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2007/09/070913081010.htm
UT Southwestern Medical Center. "Metabolic Syndrome Heightens Risk For Development Of Uric-acid Kidney Stones." ScienceDaily. www.sciencedaily.com/releases/2007/09/070913081010.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins