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Improving Liver Cancer Diagnosis

Date:
October 7, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have identified proteins that could be used to improve the diagnosis of hepatocellular carcinoma, the most common type of liver cancer. Hepatocellular carcinoma causes about one million deaths each year and is especially frequent in Asia, especially in China, where it is the second most frequent fatal cancer. But the diagnostic methods and therapies are limited, which has prompted scientists to look for proteins inside the body that indicate the presence of the disease.
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Researchers have identified proteins that could be used to improve the diagnosis of hepatocellular carcinoma, the most common type of liver cancer.

Hepatocellular carcinoma causes about one million deaths each year and is especially frequent in Asia, especially in China, where it is the second most frequent fatal cancer. But the diagnostic methods and therapies are limited, which has prompted scientists to look for proteins inside the body that indicate the presence of the disease.

Fuchu He and colleagues have used a state-of-the-art technique called two-dimensional difference gel electrophoresis to look for proteins whose copies are either increased or decreased in patients with hepatocellular carcinoma. Among the many proteins they found, two proteins were validated as novel potential markers of hepatocellular carcinoma.

Article: "Proteome Analysis of Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis," by Wei Sun, Baocai Xing, Yi Sun, Xiaojuan Du, Min Lu, Chunyi Hao, Zhuang Lu, Wei Mi, Songfeng Wu, Handong Wei, Xue Gao, Yunping Zhu, Ying Jiang, Xiaohong Qian, and Fuchu He,  Molecular & Cellular Proteomics (Vol. 6, No. 10) October 2007

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The above post is reprinted from materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


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American Society for Biochemistry and Molecular Biology. "Improving Liver Cancer Diagnosis." ScienceDaily. ScienceDaily, 7 October 2007. <www.sciencedaily.com/releases/2007/10/071005104036.htm>.
American Society for Biochemistry and Molecular Biology. (2007, October 7). Improving Liver Cancer Diagnosis. ScienceDaily. Retrieved July 7, 2015 from www.sciencedaily.com/releases/2007/10/071005104036.htm
American Society for Biochemistry and Molecular Biology. "Improving Liver Cancer Diagnosis." ScienceDaily. www.sciencedaily.com/releases/2007/10/071005104036.htm (accessed July 7, 2015).

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