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New Peritoneal Dialysis Diagnostic Discovered

Date:
October 17, 2007
Source:
University of Western Ontario
Summary:
Patients undergoing peritoneal dialysis may soon be able to worry less about the risks of infection and lessen their hospital stays.

Scientists at RobartsResearch Institute and The University of Western Ontario expect that patients undergoing peritonealdialysis may soon be able to worry less about the risks of infection and lessen their hospital stays.

Peritonealdialysis, which involves placing a tube into the peritonealcavity, allows people who have suffered from kidney failure to carry on a relatively normal life; however, complications include high incidence of infection of the abdominal cavity, known as peritonitis, which most patients experience every year or so.

Led by Joaquin Madrenas, Robartsscientist and Canada Research Chair in Immunobiologyat Western, the new study has looked at the molecule RIP2 (receptor-interacting protein 2) for clues over the past three years. Though the precise function of RIP2 is not yet known, scientists made the important finding that levels of the molecule increase during infection.

More importantly, peritonealdialysis patients with peritonitiswho have high levels of RIP2 can be sent home and treated with antibiotics. If RIP2 levels do not go up, patients risk a protracted infection and should be admitted for closer monitoring and more intense treatment. This information can be used to address the need to admit patients to the hospital.

“We currently have no objective indicator if peritonitiswill be really bad, so we tend to try to guess how bad it is,” says Madrenas. “What we have found is that, by monitoring RIP2, we can predict the outcome of the infection in patients taking part in peritonealdialysis.”

By keeping patients out of hospitals, this discovery not only helps improve quality of life, but also reduces strain on the healthcaresystem.

The team, which includes Madrenas’ PhD student MichelleMcCullyand a close collaboration with Dr. Peter Blake of the division of nephrologyat Western, will now try to adapt the discovery to a clinical laboratory and hopefully develop a diagnostic test that can be conducted with a patient’s peritonealfluid on a routine basis.

Madrenasalso wonders if there are other factors preventing RIP2 levels from increasing in some patients. “If we know what problem is preventing this increase, we could fix it and possibly prevent infections,” he says.


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Cite This Page:

University of Western Ontario. "New Peritoneal Dialysis Diagnostic Discovered." ScienceDaily. ScienceDaily, 17 October 2007. <www.sciencedaily.com/releases/2007/10/071017111144.htm>.
University of Western Ontario. (2007, October 17). New Peritoneal Dialysis Diagnostic Discovered. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2007/10/071017111144.htm
University of Western Ontario. "New Peritoneal Dialysis Diagnostic Discovered." ScienceDaily. www.sciencedaily.com/releases/2007/10/071017111144.htm (accessed September 17, 2014).

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