Featured Research

from universities, journals, and other organizations

New Peritoneal Dialysis Diagnostic Discovered

Date:
October 17, 2007
Source:
University of Western Ontario
Summary:
Patients undergoing peritoneal dialysis may soon be able to worry less about the risks of infection and lessen their hospital stays.

Scientists at RobartsResearch Institute and The University of Western Ontario expect that patients undergoing peritonealdialysis may soon be able to worry less about the risks of infection and lessen their hospital stays.

Peritonealdialysis, which involves placing a tube into the peritonealcavity, allows people who have suffered from kidney failure to carry on a relatively normal life; however, complications include high incidence of infection of the abdominal cavity, known as peritonitis, which most patients experience every year or so.

Led by Joaquin Madrenas, Robartsscientist and Canada Research Chair in Immunobiologyat Western, the new study has looked at the molecule RIP2 (receptor-interacting protein 2) for clues over the past three years. Though the precise function of RIP2 is not yet known, scientists made the important finding that levels of the molecule increase during infection.

More importantly, peritonealdialysis patients with peritonitiswho have high levels of RIP2 can be sent home and treated with antibiotics. If RIP2 levels do not go up, patients risk a protracted infection and should be admitted for closer monitoring and more intense treatment. This information can be used to address the need to admit patients to the hospital.

“We currently have no objective indicator if peritonitiswill be really bad, so we tend to try to guess how bad it is,” says Madrenas. “What we have found is that, by monitoring RIP2, we can predict the outcome of the infection in patients taking part in peritonealdialysis.”

By keeping patients out of hospitals, this discovery not only helps improve quality of life, but also reduces strain on the healthcaresystem.

The team, which includes Madrenas’ PhD student MichelleMcCullyand a close collaboration with Dr. Peter Blake of the division of nephrologyat Western, will now try to adapt the discovery to a clinical laboratory and hopefully develop a diagnostic test that can be conducted with a patient’s peritonealfluid on a routine basis.

Madrenasalso wonders if there are other factors preventing RIP2 levels from increasing in some patients. “If we know what problem is preventing this increase, we could fix it and possibly prevent infections,” he says.


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Cite This Page:

University of Western Ontario. "New Peritoneal Dialysis Diagnostic Discovered." ScienceDaily. ScienceDaily, 17 October 2007. <www.sciencedaily.com/releases/2007/10/071017111144.htm>.
University of Western Ontario. (2007, October 17). New Peritoneal Dialysis Diagnostic Discovered. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2007/10/071017111144.htm
University of Western Ontario. "New Peritoneal Dialysis Diagnostic Discovered." ScienceDaily. www.sciencedaily.com/releases/2007/10/071017111144.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins