Featured Research

from universities, journals, and other organizations

Mechanism Of Action Of EGFR Inhibitors in Cancer Chemotherapy

Date:
November 2, 2007
Source:
Public Library of Science
Summary:
Recent research considers how tumors respond to a an important class of drugs used in cancer chemotherapy, known as epidermal growth factor receptor inhibitors.

Three papers published this month in the open access general medical journal PLoS Medicine investigate how tumors respond to a an important class of drugs used in cancer chemotherapy, known as epidermal growth factor receptor (EGFR) inhibitors.

Related Articles


EGFR plays a critical role in the control of cellular proliferation, differentiation, and survival. Abnormalities in signaling of the EGFR pathway have been found in a wide range of cancers, including carcinomas of the lung, breast, and colon. Inhibitors of EGFR such as gefitinib are used in the treatment of these cancers, particularly non-small cell lung cancers which have mutations within the EGFR gene. However, the exact molecular mechanisms leading to tumor response to these drugs has been unclear.

The three independent studies with lead authors William Pao from Memorial Sloan Kettering, New York, Andreas Strasser from the Walter and Eliza Hall Institute Australia, and Susumu Kobayashi from Beth Israel Deaconess Medical Center, Boston, each investigated this pathway and show that that one protein, BIM, a member of a class of proteins that leads to apoptosis (programmed cell death) is essential for tumor cell killing by drugs such as gefitinib in cells with EGFR mutations.

These results suggest that induction of BIM may in future lead to a way of treating tumors that have developed resistance to these drugs.

The papers are further discussed in a perspective by Ingo Mellinghoff from UCLA.

Citation: Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, et al. (2007) Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas. PLoS Med 4(10): e294

Citation: Cragg MS, Kuroda J, Puthalakath H, Huang DCS, Strasser A (2007) Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med 4(10): e316.

Citation: Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, et al. (2007) BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosisin lung cancers with oncogenic EGFRmutations. PLoS Med 4(10): e315.

Citation: Mellinghoff I (2007) Why do cancer cells become "addicted" to oncogenic epidermal growth factor receptor? PLoS Med 4( 0): e321


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Mechanism Of Action Of EGFR Inhibitors in Cancer Chemotherapy." ScienceDaily. ScienceDaily, 2 November 2007. <www.sciencedaily.com/releases/2007/10/071030080656.htm>.
Public Library of Science. (2007, November 2). Mechanism Of Action Of EGFR Inhibitors in Cancer Chemotherapy. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2007/10/071030080656.htm
Public Library of Science. "Mechanism Of Action Of EGFR Inhibitors in Cancer Chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2007/10/071030080656.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins