Featured Research

from universities, journals, and other organizations

What Immune Cells See: Ins And Outs Of Peptide Processing

Date:
November 21, 2007
Source:
Journal of Clinical Investigation
Summary:
Immune cells known as T cells help us clear invading microbes, such as HIV, from our bodies, but they can also cause autoimmunity when they inappropriately attack our own tissues. T cells are activated when a receptor on their surface (the TCR) recognizes a specific complex of a peptide fragment bound to a protein known as an MHC molecule.

Immune cells known as T cells help us clear invading microbes, such as HIV, from our bodies, but they can also cause autoimmunity when they inappropriately attack our own tissues. T cells are activated when a receptor on their surface (the TCR) recognizes a specific complex of a peptide fragment bound to a protein known as an MHC molecule.

Related Articles


Defining the peptides identified by T cells mediating autoimmunity and immune responses against invading microbes, as well as harnessing this information for the design of therapeutics and vaccines, is an area of intensive investigation.

New insight into these matters is provided in the November issue of the Journal of Clinical Investigation by two studies that report technical advances in the field. The clinical implications of these are discussed in an accompanying commentary by Luc Teyton from The Scripps Research Institute, La Jolla.

Wahlstrom and colleagues from the Karolinska University Hospital, Sweden, developed a strategy to determine the peptide fragments bound by human MHC molecules activating inappropriate immune responses in vivo. Using this approach they identified 78 peptide fragments bound to the MHC molecule HLA-DR on cells isolated from the lungs of patients with sarcoidosis, an inflammatory disease of the lungs mediated largely by CD4+ T cells.

The authors suggest that this approach might be used to identify the peptides recognized by autoreactive T cells that attack the body to cause diseases such as diabetes and rheumatoid arthritis, information that could lead to the development of new treatment strategies.

By contrast, Le Gall and colleagues from Massachusetts General Hospital and Harvard Medical School, Boston, have provided insight into the peptides recognized by CD8+ T cells fighting infection with HIV. The main peptide fragment of the HIV-1 protein Gag that binds the human MHC molecule HLA-A3 is known as the immunodominant epitope.

In vitro assays determined that the amino acid sequence flanking the immunodominant epitope caused the immunodominance as moving these sequences to flank other peptides increased the frequency with which they bound HLA-A3. The authors therefore suggested that these flanking sequences might be used to enhance the effectiveness of HIV vaccines.

First journal article: Identification of HLA-DR -- bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis

Second journal article:  Portable flanking sequences modulate CTL epitope processing


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "What Immune Cells See: Ins And Outs Of Peptide Processing." ScienceDaily. ScienceDaily, 21 November 2007. <www.sciencedaily.com/releases/2007/11/071101193354.htm>.
Journal of Clinical Investigation. (2007, November 21). What Immune Cells See: Ins And Outs Of Peptide Processing. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/11/071101193354.htm
Journal of Clinical Investigation. "What Immune Cells See: Ins And Outs Of Peptide Processing." ScienceDaily. www.sciencedaily.com/releases/2007/11/071101193354.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins