Featured Research

from universities, journals, and other organizations

Novel Way To Remove Iron From Ferritin Could Dramatically Improve Sickle Cell Treatment

Date:
November 5, 2007
Source:
Children's Hospital & Research Center at Oakland
Summary:
A small protein or heptapeptide could be used to accelerate the removal of iron from ferritin, according to new research. The results of this study may help scientists develop new medications that dramatically improve the removal of excess iron in patients diagnosed with blood diseases such as B-Thalassemia (Cooley's anemia) or sickle cell disease.

A new study led by Children's Hospital Oakland Research Institute senior scientist, Elizabeth Theil, Ph.D., is the first to suggest that a small protein or heptapeptide (seven amino acids wrapped into one unit) could be used to accelerate the removal of iron from ferritin.

The results of this study may help scientists develop new medications that dramatically improve the removal of excess iron in patients diagnosed with blood diseases such as B-Thalassemia (Cooley's anemia) or Sickle Cell Disease.

The study appears in this month's issue of the Journal of Biological Chemistry and was conducted by Dr. Theil and her co-authors Xiaofeng S. Liu, postdoctoral fellow at Children's Hospital Oakland Research Institute, Marvin J. Miller, Ph.D. and Leslie D. Patterson, a predoctoral student, both from the University of Notre Dame. The scientists knew that the ferritin protein cage had pores that could open and close. It was also known that chelators (a method to detoxify blood) removed iron faster when the pores were open.

"We wanted to prove a hypothesis that a small protein or peptide could bind to ferritin and could be used to regulate ferritin pores," said Dr. Theil. "Our hypothesis was correct. We proved that when a binding peptide of seven amino acids, a heptapeptide, is coupled with Desferal the rate of removal of iron from ferritin is eight times faster." Desferal is currently used to detoxify the blood of patients with iron overload and is a common therapeutic remedy.

Ferritin is a protein that concentrates iron in its inner core or 'cage'. It plays a critical role in understanding iron overload, which can lead to a variety of symptoms including chronic fatigue, weakness, joint pain and arthritis. If left untreated, iron overload can lead to serious problems, including diabetes, liver and heart disease.

The study's results are based on laboratory tests. The National Institutes of Health (NIH), the Cooley's Anemia Foundation and Children's Hospital & Research Center Oakland provided funding for this research.


Story Source:

The above story is based on materials provided by Children's Hospital & Research Center at Oakland. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital & Research Center at Oakland. "Novel Way To Remove Iron From Ferritin Could Dramatically Improve Sickle Cell Treatment." ScienceDaily. ScienceDaily, 5 November 2007. <www.sciencedaily.com/releases/2007/11/071102161518.htm>.
Children's Hospital & Research Center at Oakland. (2007, November 5). Novel Way To Remove Iron From Ferritin Could Dramatically Improve Sickle Cell Treatment. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2007/11/071102161518.htm
Children's Hospital & Research Center at Oakland. "Novel Way To Remove Iron From Ferritin Could Dramatically Improve Sickle Cell Treatment." ScienceDaily. www.sciencedaily.com/releases/2007/11/071102161518.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins