Featured Research

from universities, journals, and other organizations

ECGC In Green Tea Is Powerful Medicine Against Severe Sepsis, Lab Study Suggests

Date:
November 13, 2007
Source:
North Shore-Long Island Jewish Health System
Summary:
A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection. An ingredient in green tea rescued mice from lethal sepsis -- and the findings could pave the way to clinical trials in patients.

A major component of green tea called EGCG could help treat severe sepsis, a new study in mice suggests.
Credit: iStockphoto/Satu Knape

A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection. In a new laboratory study, Haichao Wang, PhD, of The Feinstein Institute for Medical Research, and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis -- and the findings could pave the way to clinical trials in patients.

Related Articles


Dr. Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance, which they felt would prevent the lethal sepsis process from moving forward. And it worked.

Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available, half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis -- both on the basic biological level and in patients.

In the latest study, Dr. Wang's group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didn't receive the green tea substance to 82 percent in those who did. "Clinically, even if we could save five percent of patients, that would be huge," said Dr. Wang. "In this study, we saved 25 percent more animals with the green tea." He said that the green tea component, EGCG, is readily available.

There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. "This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines," he said. Cytokines are produced by immune cells and act as weapons to defend the body against invaders. "We are hoping to stimulate future interest in clinical studies," said Dr. Wang, who worked on the study in collaboration with Wei Li, PhD, Andrew Sama, MD, chairman of emergency medicine at North Shore University Hospital, and other Feinstein investigators.

The study was published in the Public Library of Science, or PLoS-One.

.


Story Source:

The above story is based on materials provided by North Shore-Long Island Jewish Health System. Note: Materials may be edited for content and length.


Cite This Page:

North Shore-Long Island Jewish Health System. "ECGC In Green Tea Is Powerful Medicine Against Severe Sepsis, Lab Study Suggests." ScienceDaily. ScienceDaily, 13 November 2007. <www.sciencedaily.com/releases/2007/11/071108115608.htm>.
North Shore-Long Island Jewish Health System. (2007, November 13). ECGC In Green Tea Is Powerful Medicine Against Severe Sepsis, Lab Study Suggests. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2007/11/071108115608.htm
North Shore-Long Island Jewish Health System. "ECGC In Green Tea Is Powerful Medicine Against Severe Sepsis, Lab Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2007/11/071108115608.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins