Featured Research

from universities, journals, and other organizations

Dynamical Systems Hypothesis Of Schizophrenia

Date:
November 11, 2007
Source:
Public Library of Science
Summary:
The inconsistent expressions related to schizophrenia are newly structured in a recent study. Scientists have created a dynamical system framework to better understand the symptoms of schizophrenia, which will hopefully lead to better treatment for those with the disorder.

The inconsistent expressions related to schizophrenia are newly structured in a recent study by researchers at the Universitas Pompeau Fabra (Barcelona), and Oxford University. Marco Loh, Edmund Rolls and Gustavo Deco have created a dynamical system framework to discuss the disorder.

People with schizophrenia are known to have difficulty in maintaining attention, unstable thoughts, and reduced emotions. Creating a unifying and statistical model to understand these symptoms has always posed a challenge to researchers and clinicians. For this study Loh et al. developed a top-down analytical approach based on the different types of symptoms and related them to instabilities in attractor neural networks in a statistical dynamical framework.

The researchers found that a decrease in the excitatory NMDA-mediated synaptically activated receptor conductances reduces the depth of the attractor basins, therefore reducing the stability of attention in the presence of noise caused by the statistically variable firing of neurons, thus increasing distractibility. This reduced depth in the attractor basins destabilizes the activity at the network level. The cognitive symptoms of schizophrenia (like distractibility) could be caused by this attractor instability in the prefrontal cortex

Loh et al. also found that lower firing rates are produced by reducing the excitatory (NMDA) synaptic conductances, which could account in the orbitofrontal cortex for the negative symptoms associated with schizophrenia, such as a reduction of emotions.

Decreasing both the NMDA and the inhibitory conductances results in switches between attractor states and jumps from spontaneous activity into one of the attractors. This action may cause symptoms related to temporal lobe dysfunction such as delusions and paranoia.

The dynamical framework put forth in this study may better the understanding of the symptoms of schizophrenia, therefore culminating in better treatment for those with the disorder.

Journal reference: Loh M, Rolls ET, Deco G (2007) A dynamical systems hypothesis of schizophrenia. PLoS Comput Biol 3(11): e227. doi:10.1371/journal.pcbi.0030227


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Dynamical Systems Hypothesis Of Schizophrenia." ScienceDaily. ScienceDaily, 11 November 2007. <www.sciencedaily.com/releases/2007/11/071109091101.htm>.
Public Library of Science. (2007, November 11). Dynamical Systems Hypothesis Of Schizophrenia. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2007/11/071109091101.htm
Public Library of Science. "Dynamical Systems Hypothesis Of Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2007/11/071109091101.htm (accessed October 20, 2014).

Share This



More Mind & Brain News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Court Ruling Means Kids' Online Activity Could Be On Parents

Court Ruling Means Kids' Online Activity Could Be On Parents

Newsy (Oct. 17, 2014) In a ruling attorneys for both sides agreed was a first of its kind, a Georgia appeals court said parents can be held liable for what kids put online. Video provided by Newsy
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
You Can Get Addicted To Google Glass, Apparently

You Can Get Addicted To Google Glass, Apparently

Newsy (Oct. 15, 2014) Researchers claim they’ve diagnosed the first example of the disorder in a 31-year-old U.S. Navy serviceman. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins