Featured Research

from universities, journals, and other organizations

Viral Infection Affects Important Cells' Stress Response

Date:
November 16, 2007
Source:
Baylor College of Medicine
Summary:
Viral infection disrupts the normal response of mammalian cells to outside deleterious forces, cleaving and inactivating a protein called G3BP that helps drive the formation of stress granules, which shelter the messenger RNAs that carry the code for protein formation, according to a new article.

Viral infection disrupts the normal response of mammalian cells to outside deleterious forces, cleaving and inactivating a protein called G3BP that helps drive the formation of stress granules, which shelter the messenger RNAs that carry the code for protein formation, said researchers from Baylor College of Medicine in Houston.

Only recently have scientists begun to understand the role of stress granules, said Dr. Richard Lloyd, associate professor of molecular virology and microbiology at BCM, and senior author of the report that appears November 14 in the journal Cell Host and Microbe. The stress granules are formed when a cell is subjected to several kinds of stress, such as nutrient deprivation or virus infection.

"When the cell suffers a major insult, it stops expanding. The business of protein synthesis (in which messenger RNA or mRNA's genetic code gets translated into proteins that carry out cellular activities) is arrested. The messenger RNA goes into storage until conditions improve for the cells," he said. "Stress granules are a major storage site for the mRNA."

However, in poliovirus infection (used in the laboratory because it is a prototype for many kinds of viruses), the stress granules are formed early but as the infection continues, the stress granules disperse.

Lloyd and his colleagues found that the poliovirus infection actually cuts or cleaves G3BP, a protein critical in the formation of the stress granules.

"The cells respond to the viral infection, and then virus is shutting that response off," said Lloyd. In effect, he said, this type of cell response helps prevent the virus from translating its mRNA into virus proteins and killing the cells.

Other viruses may affect other proteins important in this type of stress response, said Lloyd. "Poliovirus has evolved to target G3BP," he said.

When he and his colleagues mutated G3BP to make it resistant to being cut or cleaved, they found that stress granules could be formed during virus infection and that this inhibited virus growth in the cells.

"With the cleavage resistant form, the cells can continue to make stress granules, and this interferes with virus reproduction" he said.

Others who took part in this work include James P. White, Ana Maria Cardenas and Wilfred E. Marissen, all of BCM. Funding for this work came from the National Institutes of Health.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College of Medicine. "Viral Infection Affects Important Cells' Stress Response." ScienceDaily. ScienceDaily, 16 November 2007. <www.sciencedaily.com/releases/2007/11/071114121323.htm>.
Baylor College of Medicine. (2007, November 16). Viral Infection Affects Important Cells' Stress Response. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/11/071114121323.htm
Baylor College of Medicine. "Viral Infection Affects Important Cells' Stress Response." ScienceDaily. www.sciencedaily.com/releases/2007/11/071114121323.htm (accessed July 28, 2014).

Share This




More Plants & Animals News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
The New York Times Backs Pot Legalization

The New York Times Backs Pot Legalization

Newsy (July 27, 2014) The New York Times has officially endorsed the legalization of marijuana, but why now, and to what end? Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins