Featured Research

from universities, journals, and other organizations

Enzymes Key To Brainpower Identified

Date:
November 16, 2007
Source:
Massachusetts Institute of Technology
Summary:
Bolstering disintegrating neural connections may help boost brainpower in Alzheimer's disease patients. Researchers zeroed in on the enzymes that manipulate a key scaffolding protein for synapses, the connections through which brain cells communicate. Synapses are weakened and lost in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Professor Morgan Sheng, Menicon Professor of Neuroscience at MIT's Picower Center for Learning and Memory, joins post-doc Myung Jong Kim, right, in the lab. They have shown how manipulating a brain scaffolding protein called PSD-95 could boost cognitive function.
Credit: Photo / Donna Coveney

Bolstering disintegrating neural connections may help boost brainpower in Alzheimer's disease patients, MIT researchers and colleagues will report in the Nov. 8 issue of Neuron.

The researchers zeroed in on the enzymes that manipulate a key scaffolding protein for synapses, the connections through which brain cells communicate. Synapses are weakened and lost in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

"We identified a major underlying mechanism through which synapses are strengthened and maintained," said Morgan H. Sheng, Menicon Professor of Neuroscience at MIT's Picower Institute for Learning and Memory. "The enzymes involved could be good targets for potential drug treatments."

A protein called postsynaptic density-95 (PSD-95) is a key building block of synapses. Like the steel girders in a building, it acts as a scaffold around which other components are assembled. "The more PSD-95 molecules, the bigger and stronger the synapse," said co-author Myung Jong Kim, a Picower research scientist.

Previous research had shown that mice genetically altered to have less PSD-95 experienced learning and memory problems.

In the current study, the researchers identified for the first time the enzymes that work behind the scenes on PSD-95, adding a phosphate group to a specific amino acid in the PSD-95 protein. This process--called phosphorylation--is critical for PSD-95 to do its job in supporting synapses.

"Adding a phosphate group to a single amino acid allows PSD-95 to promote synapse size and strength," said Sheng, who also holds an appointment in MIT's Department of Brain and Cognitive Sciences and is a Howard Hughes Medical Institute investigator. "Therefore, promoting this process could help improve cognitive function."

Sheng believes manipulating PSD-95 through phosphorylation could lead to bigger and more robust synapses, which would boost brainpower in both normal and diseased brains. "It's possible that promoting PSD-95 phosphorylation could also help neuropsychiatric illnesses in which synapse function goes awry, such as schizophrenia, depression and autism," Sheng said.

In addition to Sheng and Kim, authors include Picower research scientist Kensuke Futai; Yasunori Hayashi, MIT assistant professor of neurobiology and RIKEN-MIT investigator; and Jihoon Yu and Kwangwook Cho of the University of Bristol in England.

This research is supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Massachusetts Institute of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts Institute of Technology. "Enzymes Key To Brainpower Identified." ScienceDaily. ScienceDaily, 16 November 2007. <www.sciencedaily.com/releases/2007/11/071114200236.htm>.
Massachusetts Institute of Technology. (2007, November 16). Enzymes Key To Brainpower Identified. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2007/11/071114200236.htm
Massachusetts Institute of Technology. "Enzymes Key To Brainpower Identified." ScienceDaily. www.sciencedaily.com/releases/2007/11/071114200236.htm (accessed April 18, 2014).

Share This



More Mind & Brain News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study On Artists' Brain Shows They're 'Structurally Unique'

Study On Artists' Brain Shows They're 'Structurally Unique'

Newsy (Apr. 17, 2014) The brains of artists aren't really left-brain or right-brain, but rather have extra neural matter in visual and motor control areas. Video provided by Newsy
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Are School Dress Codes Too Strict?

Are School Dress Codes Too Strict?

AP (Apr. 16, 2014) Pushing the limits on style and self-expression is a rite of passage for teens and even younger kids. How far should schools go with their dress codes? The courts have sided with schools in an era when school safety is paramount. (April 16) Video provided by AP
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins