Featured Research

from universities, journals, and other organizations

Scientists Strike Blow In Superbugs Struggle

Date:
December 11, 2007
Source:
University of Manchester
Summary:
Scientists have pioneered new ways of tweaking the molecular structure of antibiotics -- an innovation that could be crucial in the fight against powerful superbugs. They have paved the way for the development of new types of antibiotics capable of fighting increasingly resistant bacteria.

Scientists from The University of Manchester have pioneered new ways of tweaking the molecular structure of antibiotics -- an innovation that could be crucial in the fight against powerful super bugs.

Related Articles


The work was led by chemical biologist Dr Jason Micklefield in collaboration with geneticist Professor Colin Smith.

Scientists working in The School of Chemistry and the Manchester Interdisciplinary Biocentre have paved the way for the development of new types of antibiotics capable of fighting increasingly resistant bacteria.

Micklefield, Smith and colleagues were the first to engineer the biosynthesis of lipopeptide antibiotics of this class back in 2002. They have now developed methodologies for altering the structure of these antibiotics, such as mutating, adding and deleting components.

This innovation provides access to thousands of lipopeptide variants that cannot be produced easily in any other way.

Dr Micklefield said: "The results from this work are essential in the development of the next generation of lipopeptide antibiotics, which are critical to combat emerging super bugs that have acquired resistance to other antibiotics.

"The potent activity of this class of antibiotics against pathogens that are resistant to all current antibiotic treatments makes them one of the most important groups of antibiotics available.

"Our work relies on interdisciplinary chemical-biology, spanning chemistry through to molecular genetics. It follows the tradition of pioneering work in natural product biosynthesis and engineering that has come out of the UK."

Scientists in Manchester have been doing work on calcium dependent antibiotics (CDA), which belong to the same family of acidic lipopeptides as daptomycin.

In 2003 daptomycin became the first new structural class of natural antibiotic to reach hospitals in more than 30 years.

But researchers say there is already evidence that bacteria are evolving and becoming resistant to daptomycin -- leading to the emergence of dangerous new super bugs.

Dr Micklefield added: "If we are to successfully fight and control potent new super bugs in the future, we need to be developing the next generation of antibiotics now."

The research carried out by Dr Mickelfield and his colleagues is part of a larger 650,000 project called 'Combinatorial biosynthesis of lipopeptide antibiotics', which is funded by the BBSRC and supported by drug discovery company Biotica. It is concerned with elucidating and engineering biosynthetic pathways leading to complex nonribosomal lipopeptide antibiotics.

'Engineered biosynthesis of non-ribosomal lipopeptides with modified fatty acid side chains' was published online December 5 and will also appear a forthcoming print issue of the Journal of the American Chemical Society.

Funding was provided by the UK's Biotechnology and Biological Sciences Research Council.


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Cite This Page:

University of Manchester. "Scientists Strike Blow In Superbugs Struggle." ScienceDaily. ScienceDaily, 11 December 2007. <www.sciencedaily.com/releases/2007/12/071205095326.htm>.
University of Manchester. (2007, December 11). Scientists Strike Blow In Superbugs Struggle. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2007/12/071205095326.htm
University of Manchester. "Scientists Strike Blow In Superbugs Struggle." ScienceDaily. www.sciencedaily.com/releases/2007/12/071205095326.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com
Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins