Featured Research

from universities, journals, and other organizations

HIV-infected Infants Respond Poorly To Childhood Vaccination

Date:
December 7, 2007
Source:
Public Library of Science
Summary:
It is known that HIV-infected children who do not receive appropriate antiretroviral drugs experience immune depression, and may become susceptible to infectious diseases that would otherwise be prevented by childhood immunization. It is therefore important to find out to what extent HIV-infected children are able to generate adequate levels of antibodies following routine childhood immunizations. A new article describes the results of a cross-sectional study carried out amongst 18-36 month-old children born to HIV-infected mothers and living in Central Africa. The study suggested that immuno-suppressed HIV-infected children have a low persistence of antibodies to the vaccines of the Expanded Program on Immunization.

It is known that HIV-infected children who do not receive appropriate antiretroviral drugs experience immune depression, and may become susceptible to infectious diseases that would otherwise be prevented by childhood immunization.

It is therefore important to find out to what extent HIV-infected children are able to generate adequate levels of antibodies following routine childhood immunizations.

A new article describes the results of a cross-sectional study carried out amongst 18-36 month-old children born to HIV-infected mothers and living in Central Africa. The study suggested that immuno-suppressed HIV-infected children have a low persistence of antibodies to the vaccines of the Expanded Program on Immunization (EPI, WHO).

The study was conducted in Cameroon and the Central African Republic by pediatricians, epidemiologists, bacteriologists and virologists, and coordinated by the Institut Pasteur (Paris, France) through its International Network, particularly the institutes based at the Pasteur Center in Yaoundι and at the Institut Pasteur in Bangui.

The researchers found that antibody levels to measles vaccine was particularly low amongst children who were HIV infected, and that antibody levels to vaccine amongst HIV-uninfected children born to HIV-infected mothers were lower than expected. This latter finding raises the possibility that HIV exposure during pregnancy might influence the response to EPI vaccines in the first weeks of life. These results suggest that children living with HIV may need an adapted EPI vaccine schedule.

Journal citation: Tejiokem MC, Gouandjika I, Be΄niguel L, Zanga Marie-Claire E, Tene G, et al (2007) HIV-Infected Children Living in Central Africa Have Low Persistence of Antibodies to Vaccines Used in the Expanded Program on Immunization. PLoS One 2(12): e1260. doi:10.1371/journal.pone.0001260


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "HIV-infected Infants Respond Poorly To Childhood Vaccination." ScienceDaily. ScienceDaily, 7 December 2007. <www.sciencedaily.com/releases/2007/12/071205095404.htm>.
Public Library of Science. (2007, December 7). HIV-infected Infants Respond Poorly To Childhood Vaccination. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2007/12/071205095404.htm
Public Library of Science. "HIV-infected Infants Respond Poorly To Childhood Vaccination." ScienceDaily. www.sciencedaily.com/releases/2007/12/071205095404.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) — The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins