Featured Research

from universities, journals, and other organizations

Biomarkers For Inflammatory Disease

Date:
December 7, 2007
Source:
BioMed Central
Summary:
Gene-expression profiles might be used to identify prognostic biomarkers for Kawasaki disease, and help to unravel the underlying biology of the illness. The new findings also support the idea that gene-expression profiles might be used to generate biomarkers for other systemic inflammatory illnesses.

Gene-expression profiles might be used to identify prognostic biomarkers for Kawasaki disease, and help to unravel the underlying biology of the illness, research published this week in the online open access journal Genome Biology reveals. The new findings also support the idea that gene-expression profiles might be used to generate biomarkers for other systemic inflammatory illnesses.

Related Articles


Kawasaki disease, an acute, self-limited vasculitis, is the leading cause of acquired heart disease in children in developed countries, but its aetiologic and pathogenic mechanisms remain unclear.

A team of researchers led by David Relman, Stanford University, US, and Jane Burns, University of California at San Diego, US, characterized the gene expression patterns that occur in the blood cells of patients with this disease. They examined genome-wide transcript expression patterns in the blood of 77 children with Kawasaki disease. The acute phase of the illness was accompanied by an increase in gene transcripts associated with innate immune mechanisms and proinflammatory responses, and a decrease in transcripts associated with natural killer cells and CD8+ lymphocytes, which help clear infected or abnormal cells from the body.

They showed that the transcript patterns during the acute phase of the disease varied dramatically with day of illness, and that differences in expression patterns between patients were associated with clinical parameters that physicians have used to manage and make predictions about the course of the disease.

Patients who showed higher expression levels of specific transcripts (e.g., carcinoembryonic antigen-related cell adhesion molecule 1; CEACAM1) were less likely to respond to intravenous immunoglobulin, a highly effective but poorly understood treatment for preventing coronary artery aneurysms and reducing fever in Kawasaki disease.

This work contributes to our understanding of how the disease develops, how the treatment works, and how doctors might identify patients who are candidates for other therapies.

Article: Patrick O Brown, Jane C Burns and David A Relman. Gene-expression patterns reveal underlying biological processes in Kawasaki disease Stephen J Popper, Chisato Shimizu, Hiroko Shike, John T Kanegaye, Robert P Sundel, Jane W Newburger. Genome Biology (in press) (http://genomebiology.com/)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Biomarkers For Inflammatory Disease." ScienceDaily. ScienceDaily, 7 December 2007. <www.sciencedaily.com/releases/2007/12/071205190919.htm>.
BioMed Central. (2007, December 7). Biomarkers For Inflammatory Disease. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/12/071205190919.htm
BioMed Central. "Biomarkers For Inflammatory Disease." ScienceDaily. www.sciencedaily.com/releases/2007/12/071205190919.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins