Featured Research

from universities, journals, and other organizations

Protein Fingerprinting Made Easy

Date:
December 19, 2007
Source:
Rudjer Boskovic Institute
Summary:
Combining some traditional experimental methods of molecular biology with computational methods of artificial intelligence, scientists have demonstrated a novel approach for producing 'protein fingerprints' of diverse tissues. This result could lead to the development of new convenient methods in medical diagnostics. Being directly responsible for a great majority of processes in living cells, proteins are the most important class of biological molecules.

Combining some traditional experimental methods of molecular biology with computational methods of artificial intelligence, a group of researchers from Ruder Boškovic Instititute and Faculty of Natural Sciences and Mathematics from Zagreb, Croatia, demonstrated a novel approach for producing ‘protein fingerprints’ of diverse tissues. This result could lead to the development of new convenient methods in medical diagnostics.

Being directly responsible for a great majority of processes in living cells, proteins are the most important class of biological molecules. They are literally ‘molecular machines’ which facilitate the import of nutrients into the cell and expulsion of waste products from it, production of energy and transportation of material within the cell, as well as cellular respiration and mechanical motion. Due to their immense importance, proteins are among the most vigorously studied topics in biology today.

Over half a million different protein species have been identified in humans, each of them related to particular types of human cells. Different tissues, such as muscles, bones, nerves or skin, are distinguished by the unique ‘protein fingerprint’ – the specific relative abundance of different proteins contained in their cells. Moreover, pathological changes in any type of tissue necessarily have an impact on the tissue’s protein composition, and therefore protein fingerprinting can be used for early diagnostics and identification of various diseases such as tumors or infections.

Unfortunately, producing a good quality protein fingerprint has until now been a complicated, time consuming and expensive enterprise. However, based on their research of tumors conducted on horseradish plant tissue, the Croatian team proposed a novel approach to bypass this obstacle.

Applying computational methods of artificial intelligence, they ‘trained’ a computer to precisely extract the most relevant information on the protein fingerprint from rather ‘fuzzy’ experimental data obtained by 1D protein electrophoresis, a well known, simple, quick and cheap experimental method of molecular biology. Their result hence opens up the possibility for development of a cheap, convenient and reliable method for producing good quality protein fingerprints.

The study 'Enhanced analytical power of SDS-PAGE using machine learning algorithms' will be published in the January issue of “Proteomics” (DOI 10.1002/pmic.200700555)


Story Source:

The above story is based on materials provided by Rudjer Boskovic Institute. Note: Materials may be edited for content and length.


Cite This Page:

Rudjer Boskovic Institute. "Protein Fingerprinting Made Easy." ScienceDaily. ScienceDaily, 19 December 2007. <www.sciencedaily.com/releases/2007/12/071216133823.htm>.
Rudjer Boskovic Institute. (2007, December 19). Protein Fingerprinting Made Easy. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2007/12/071216133823.htm
Rudjer Boskovic Institute. "Protein Fingerprinting Made Easy." ScienceDaily. www.sciencedaily.com/releases/2007/12/071216133823.htm (accessed September 19, 2014).

Share This



More Plants & Animals News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com
Chimp Violence Study Renews Debate On Why They Kill

Chimp Violence Study Renews Debate On Why They Kill

Newsy (Sep. 17, 2014) The study weighs in on a debate over whether chimps are naturally violent or become that way due to human interference in the environment. Video provided by Newsy
Powered by NewsLook.com
Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins