Featured Research

from universities, journals, and other organizations

Protein Fingerprinting Made Easy

Date:
December 19, 2007
Source:
Rudjer Boskovic Institute
Summary:
Combining some traditional experimental methods of molecular biology with computational methods of artificial intelligence, scientists have demonstrated a novel approach for producing 'protein fingerprints' of diverse tissues. This result could lead to the development of new convenient methods in medical diagnostics. Being directly responsible for a great majority of processes in living cells, proteins are the most important class of biological molecules.

Combining some traditional experimental methods of molecular biology with computational methods of artificial intelligence, a group of researchers from Ruder Boškovic Instititute and Faculty of Natural Sciences and Mathematics from Zagreb, Croatia, demonstrated a novel approach for producing ‘protein fingerprints’ of diverse tissues. This result could lead to the development of new convenient methods in medical diagnostics.

Related Articles


Being directly responsible for a great majority of processes in living cells, proteins are the most important class of biological molecules. They are literally ‘molecular machines’ which facilitate the import of nutrients into the cell and expulsion of waste products from it, production of energy and transportation of material within the cell, as well as cellular respiration and mechanical motion. Due to their immense importance, proteins are among the most vigorously studied topics in biology today.

Over half a million different protein species have been identified in humans, each of them related to particular types of human cells. Different tissues, such as muscles, bones, nerves or skin, are distinguished by the unique ‘protein fingerprint’ – the specific relative abundance of different proteins contained in their cells. Moreover, pathological changes in any type of tissue necessarily have an impact on the tissue’s protein composition, and therefore protein fingerprinting can be used for early diagnostics and identification of various diseases such as tumors or infections.

Unfortunately, producing a good quality protein fingerprint has until now been a complicated, time consuming and expensive enterprise. However, based on their research of tumors conducted on horseradish plant tissue, the Croatian team proposed a novel approach to bypass this obstacle.

Applying computational methods of artificial intelligence, they ‘trained’ a computer to precisely extract the most relevant information on the protein fingerprint from rather ‘fuzzy’ experimental data obtained by 1D protein electrophoresis, a well known, simple, quick and cheap experimental method of molecular biology. Their result hence opens up the possibility for development of a cheap, convenient and reliable method for producing good quality protein fingerprints.

The study 'Enhanced analytical power of SDS-PAGE using machine learning algorithms' will be published in the January issue of “Proteomics” (DOI 10.1002/pmic.200700555)


Story Source:

The above story is based on materials provided by Rudjer Boskovic Institute. Note: Materials may be edited for content and length.


Cite This Page:

Rudjer Boskovic Institute. "Protein Fingerprinting Made Easy." ScienceDaily. ScienceDaily, 19 December 2007. <www.sciencedaily.com/releases/2007/12/071216133823.htm>.
Rudjer Boskovic Institute. (2007, December 19). Protein Fingerprinting Made Easy. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/12/071216133823.htm
Rudjer Boskovic Institute. "Protein Fingerprinting Made Easy." ScienceDaily. www.sciencedaily.com/releases/2007/12/071216133823.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins