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A Faster, Simpler Test For Disease Biomarkers

Date:
December 19, 2007
Source:
American Chemical Society
Summary:
In an advance toward earlier diagnosis of cancer and other disorders, scientists are reporting development of a potentially fast, simple and inexpensive blood test to detect disease "biomarkers." They explain that serum biomarkers can reveal critical information about the onset and progression of many diseases. Several roadblocks hinder clinical use of existing biomarker tests, which will demand smaller sensors, faster detection times, and less expensive ways of analyzing samples of blood and other body fluids.

In an advance toward earlier diagnosis of cancer and other disorders, scientists are reporting development of a potentially fast, simple and inexpensive blood test to detect disease "biomarkers."

Cagri A. Savran and colleagues explain that serum biomarkers can reveal critical information about the onset and progression of many diseases. Several roadblocks hinder clinical use of existing biomarker tests, which will demand smaller sensors, faster detection times, and less expensive ways of analyzing samples of blood and other body fluids.

The study describes development of an integrated serum biomarker detection system for the folate receptor and testing of blood samples from patients with different types of cancer. Researchers captured the folate receptors -- proteins that are biomarkers for the growth of cancer cells -- with microscopic magnetic beads and assembled them to form a structure termed a "diffraction grating." A laser beam focused on the grating yielded a pattern that could potentially be used to determine the biomarker concentration and thus the state of tumor growth.

"The same principles presented here should apply for detection of many other disease markers present in various body fluids," the researchers stated. "Due to its simplicity and high sensitivity, we expect this method to be extremely useful both in research laboratories and in development of devices for point-of-care diagnostics."

The study, "Immunomagnetic Diffractometry for Detection of Diagnostic Serum Markers," is scheduled for the Dec. 26 issue of ACS' Journal of the American Chemical Society.


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


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American Chemical Society. "A Faster, Simpler Test For Disease Biomarkers." ScienceDaily. ScienceDaily, 19 December 2007. <www.sciencedaily.com/releases/2007/12/071217105657.htm>.
American Chemical Society. (2007, December 19). A Faster, Simpler Test For Disease Biomarkers. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2007/12/071217105657.htm
American Chemical Society. "A Faster, Simpler Test For Disease Biomarkers." ScienceDaily. www.sciencedaily.com/releases/2007/12/071217105657.htm (accessed October 1, 2014).

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