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EPO Prevents Chemotherapy Cardiotoxicity, Study Suggests

Date:
December 26, 2007
Source:
Society for Experimental Biology and Medicine
Summary:
The use of several chemotherapeutic agents in oncology is limited by their cardiac toxicity. Recent experimental studies suggest that recombinant human erythropoietin (rhEPO) can be considered as a protective agent against cardiac ischemic injury. Here we show that pretreatment by rhEPO protects myocardium against cardiotoxicity induced by acute doxorubicin or trastuzumab exposure, using the isolated rat heart model. Further clinical investigations are now needed to explore the potential benefit of rhEPO in oncology.
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Researchers at the University of Grenoble, in France, have discovered that erythropoietin administration prevents acute cardiotoxic effects induced by doxorubicin and trastuzumab exposures.  Although rare, cardiotoxicity is a serious complication of cancer treatment. Indeed, the use of chemotherapeutic agents such as anthracycline or trastuzumab in oncology is limited by their cardiac toxicity. Therefore, it is of interest to identify new protective agents preventing these adverse effects.

"The increasing use of doxorubicin and trastuzumab in adjuvant breast cancer therapy and the growing population of long-term pediatric cancer survivors mean that, more than ever, cardiotoxicity will continue to remain an important issue for oncology. Cardiomyopathy induced by chronic chemotherapy may result, at least in part, from acute cardiotoxic effects accompanying each drug exposure." said Professor Mireille Mousseau, head of the Department of Oncology.

The research team, led by Christophe Ribuot, a professor of pharmacology, explored the beneficial cardioprotective effect afforded by recombinant human erythropoietin (rhEPO) against various stresses, through experimental and clinical investigations.

"We observed for the first time that only a unique rhEPO administration prevents cardiac damage induced by an acute doxorubicin or trastuzumab exposure, using the isolated rat heart model." said the article's first author Amandine Ramond. "RhEPO administration could, therefore, be used during chemotherapy administration to reduce acute cardiotoxic effects accompanying each drug exposure and, potentially, to prevent long-term development of cardiomyopathy. Further clinical investigations are now needed to explore the potential benefit of rhEPO in oncology."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Amandine Ramond and her colleagues have provided an insightful study demonstrating that rhEPO can reduce the cardiotoxic effects of chemotherapeutic agents, doxorubicin and trastzumab, in a rat heart model. If rhEPO has similar effects on humans then this study will be of substantial benefit to cancer patients worldwide."

The research article describing this work entitled "Erythropoietin pretreatment protects against acute chemotherapy toxicity in isolated rat hearts" will be featured in the January 2008 issue of Experimental Biology and Medicine.


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The above post is reprinted from materials provided by Society for Experimental Biology and Medicine. Note: Materials may be edited for content and length.


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Society for Experimental Biology and Medicine. "EPO Prevents Chemotherapy Cardiotoxicity, Study Suggests." ScienceDaily. ScienceDaily, 26 December 2007. <www.sciencedaily.com/releases/2007/12/071220123841.htm>.
Society for Experimental Biology and Medicine. (2007, December 26). EPO Prevents Chemotherapy Cardiotoxicity, Study Suggests. ScienceDaily. Retrieved July 30, 2015 from www.sciencedaily.com/releases/2007/12/071220123841.htm
Society for Experimental Biology and Medicine. "EPO Prevents Chemotherapy Cardiotoxicity, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2007/12/071220123841.htm (accessed July 30, 2015).

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