Featured Research

from universities, journals, and other organizations

What Tips The Balance? Understanding Why X Chromosome Inactivation Can Be Skewed

Date:
December 26, 2007
Source:
Journal of Clinical Investigation
Summary:
To ensure that women and men express equivalent levels of the genes found on X chromosomes, one of the two X chromosomes in the cells of a women is inactive. X chromosome inactivation (XCI) occurs early in development, at approximately the time an embryo implants in the womb, and all cells stemming from a given cell have the same X chromosome inactivated.

To ensure that women and men express equivalent levels of the genes found on X chromosomes, one of the two X chromosomes in the cells of a women is inactive. X chromosome inactivation (XCI) occurs early in development, at approximately the time an embryo implants in the womb, and all cells stemming from a given cell have the same X chromosome inactivated.

Which X chromosome is inactivated is random and most females have approximately equal numbers of cells with each X chromosome inactivated. However, some individuals have a much greater proportion of their cells with a given X chromosome inactivated.

Such skewing of XCI can have clinical implications, for example, increased XCI skewing has been linked to premature ovarian failure and recurrent spontaneous abortion. To use XCI skewing effectively as a clinical tool more information is needed about the underlying mechanisms.

In a new study, Lambert Busque and colleagues at the University of Montreal, have shown that XCI skewing is a complex trait determined by secondary events and selection biases rather than being the result of an inherited tendency to inactivate a particular X chromosome.

Carolyn Brown and colleagues from the University of British Columbia, Vancouver, highlight the importance of these observations in an accompanying commentary.

Article: No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. Journal of Clinical Investigation. December 20, 2007.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "What Tips The Balance? Understanding Why X Chromosome Inactivation Can Be Skewed." ScienceDaily. ScienceDaily, 26 December 2007. <www.sciencedaily.com/releases/2007/12/071220172123.htm>.
Journal of Clinical Investigation. (2007, December 26). What Tips The Balance? Understanding Why X Chromosome Inactivation Can Be Skewed. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/12/071220172123.htm
Journal of Clinical Investigation. "What Tips The Balance? Understanding Why X Chromosome Inactivation Can Be Skewed." ScienceDaily. www.sciencedaily.com/releases/2007/12/071220172123.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins