Featured Research

from universities, journals, and other organizations

How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity

Date:
December 29, 2007
Source:
Journal of Clinical Investigation
Summary:
Not all individuals who have epilepsy respond to traditional treatments. Strict adherence to a ketogenic diet high in fats and extremely low in carbohydrates is sometimes used to treat these patients. A new study shows that intranasal delivery of leptin, a hormone important in feeding and energy metabolism, delays the onset of convulsions in rodents, leading to the suggestion that leptin-triggered signaling may be a key to how a ketogenic diet combats epilepsy.

Not all individuals who have epilepsy respond to traditional treatments and these individuals are said to have medically refractory epilepsy.

Related Articles


Strict use of a ketogenic diet high in fats and extremely low in carbohydrates is sometimes used for treatment of refractory epilepsy, and is effective about half of the time.

However, the mechanisms whereby ketogenic diets suppress epileptic symptoms have long been a mystery. New data generated by Kelvin Yamada and colleagues at the Washington University School of Medicine, St. Louis, has revealed that intranasal delivery of leptin, a hormone important in feeding and energy metabolism, delayed the onset of convulsions in a rodent model of seizures.

As indicated by Tamas Horvath and Sabrina Diano in an accompanying commentary, these data suggest that leptin-triggered signaling may be a key to how a ketogenic diet combats epilepsy.

In the study, when focal seizures were induced by injection of the chemical 4AP into rat brains, co-injection of leptin reduced both the length and the frequency of these seizures. Intranasal administration permitted leptin to cross the blood-brain barrier and delay the onset of chemical-induced generalized seizures in mice.

Additional experiments revealed that leptin may assert these antiseizure effects via interaction with the JAK2/PI3K signaling pathway.

The authors concluded that successful epilepsy treatments may include dietary changes to increase leptin levels, intranasal administration of the compound, and pharmacological targeting of JAK2/PI3K signaling pathways.

Article: Leptin inhibits 4-aminopyridine-- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. Journal of Clinical Investigation. December 20, 2007.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity." ScienceDaily. ScienceDaily, 29 December 2007. <www.sciencedaily.com/releases/2007/12/071220172129.htm>.
Journal of Clinical Investigation. (2007, December 29). How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2007/12/071220172129.htm
Journal of Clinical Investigation. "How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity." ScienceDaily. www.sciencedaily.com/releases/2007/12/071220172129.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins