Featured Research

from universities, journals, and other organizations

How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity

Date:
December 29, 2007
Source:
Journal of Clinical Investigation
Summary:
Not all individuals who have epilepsy respond to traditional treatments. Strict adherence to a ketogenic diet high in fats and extremely low in carbohydrates is sometimes used to treat these patients. A new study shows that intranasal delivery of leptin, a hormone important in feeding and energy metabolism, delays the onset of convulsions in rodents, leading to the suggestion that leptin-triggered signaling may be a key to how a ketogenic diet combats epilepsy.

Not all individuals who have epilepsy respond to traditional treatments and these individuals are said to have medically refractory epilepsy.

Related Articles


Strict use of a ketogenic diet high in fats and extremely low in carbohydrates is sometimes used for treatment of refractory epilepsy, and is effective about half of the time.

However, the mechanisms whereby ketogenic diets suppress epileptic symptoms have long been a mystery. New data generated by Kelvin Yamada and colleagues at the Washington University School of Medicine, St. Louis, has revealed that intranasal delivery of leptin, a hormone important in feeding and energy metabolism, delayed the onset of convulsions in a rodent model of seizures.

As indicated by Tamas Horvath and Sabrina Diano in an accompanying commentary, these data suggest that leptin-triggered signaling may be a key to how a ketogenic diet combats epilepsy.

In the study, when focal seizures were induced by injection of the chemical 4AP into rat brains, co-injection of leptin reduced both the length and the frequency of these seizures. Intranasal administration permitted leptin to cross the blood-brain barrier and delay the onset of chemical-induced generalized seizures in mice.

Additional experiments revealed that leptin may assert these antiseizure effects via interaction with the JAK2/PI3K signaling pathway.

The authors concluded that successful epilepsy treatments may include dietary changes to increase leptin levels, intranasal administration of the compound, and pharmacological targeting of JAK2/PI3K signaling pathways.

Article: Leptin inhibits 4-aminopyridine-- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. Journal of Clinical Investigation. December 20, 2007.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity." ScienceDaily. ScienceDaily, 29 December 2007. <www.sciencedaily.com/releases/2007/12/071220172129.htm>.
Journal of Clinical Investigation. (2007, December 29). How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/12/071220172129.htm
Journal of Clinical Investigation. "How An Atkins-like Diet Can Treat Epilepsy: Leptin Attenuates Rodent Seizure Severity." ScienceDaily. www.sciencedaily.com/releases/2007/12/071220172129.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins