Featured Research

from universities, journals, and other organizations

Breaking Down The Potential Molecular Mechanisms Underlying Parkinson Disease

Date:
January 7, 2008
Source:
Journal of Clinical Investigation
Summary:
New data generated in vitro and in cultured cell lines and mouse neurons has shed light on the mechanisms by which the protein alpha-synuclein is degraded in brain cells known as neurons. This has implications for the development of the neurodegenerative disorder Parkinson disease (PD) because altered degradation of alpha-synuclein has been implicated as a key step in the development of the disorder.

New data generated in vitro and in cultured cell lines and mouse neurons, by Ana Maria Cuervo and colleagues at the Albert Einstein College of Medicine, New York, has shed light on the mechanisms by which the protein alpha-synuclein is degraded in brain cells known as neurons.

This has implications for the development of the neurodegenerative disorder Parkinson disease (PD) because altered degradation of alpha-synuclein has been implicated as a key step in the development of the disorder.

In the study, posttranslational modification of alpha-synuclein by processes such as by phosphorylation and nitration was shown to impair degradation of this protein by a mechanism known as chaperone-mediated autophagy (CMA) in isolated lysosomes, cultured dopaminergic cell lines, and cultured mouse neurons. Of relevance to PD, in which most of the neurons lost are dopaminergic neurons of the substantia nigra, dopamine-modified alpha-synuclein was poorly degraded by CMA and blocked the degradation of other proteins by CMA.

The authors therefore suggested that dopamine-induced inhibition of alpha-synuclein degradation by CMA increases the vulnerability of dopaminergic neurons to cellular stressors, thereby explaining the selective loss of dopaminergic neurons in individuals with PD.

Journal article: Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. Journal of Clinical Investigation. January 2, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Breaking Down The Potential Molecular Mechanisms Underlying Parkinson Disease." ScienceDaily. ScienceDaily, 7 January 2008. <www.sciencedaily.com/releases/2008/01/080102222921.htm>.
Journal of Clinical Investigation. (2008, January 7). Breaking Down The Potential Molecular Mechanisms Underlying Parkinson Disease. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2008/01/080102222921.htm
Journal of Clinical Investigation. "Breaking Down The Potential Molecular Mechanisms Underlying Parkinson Disease." ScienceDaily. www.sciencedaily.com/releases/2008/01/080102222921.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins