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Identification Of A Novel Neural Stem Cell Type

Date:
January 16, 2008
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells. In culture, neural stem cells (NSCs) can readily differentiate into neuronal and glial subtypes, but their ability to differentiate into region-specific neuronal cell types is limited.
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Researchers from the Sloan-Kettering Institute, led by Dr. Lorenz Studer, have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells.

In culture, neural stem cells (NSCs) can readily differentiate into neuronal and glial subtypes, but their ability to differentiate into region-specific neuronal cell types is limited. Dr. Studer and colleagues isolated and cloned a population of neural rosette cells (R-NSCs), which have an expanded neuronal subtype differentiation potential.

Dr. Studer and colleagues demonstrate that R-NSCs can differentiate along both the CNS and PNS lineages, and are capable of in vivo engraftment. Furthermore, the researchers identified biomarkers unique to the R-NSC type, as well as signaling pathways required for the maintenance of the R-NSC type.

"Our data suggest that R-NSCs may represent the first neural cell type capable of recreating the full cellular diversity of the mammalian nervous system. As such, R-NSCs should have a major impact for applications in regenerative medicine and have the potential to become the "embryonic stem cell equivalent" of the nervous system," explains Dr. Studer.

This research is published in a recent issue of Genes and Development.


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The above post is reprinted from materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


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Cold Spring Harbor Laboratory. "Identification Of A Novel Neural Stem Cell Type." ScienceDaily. ScienceDaily, 16 January 2008. <www.sciencedaily.com/releases/2008/01/080114173921.htm>.
Cold Spring Harbor Laboratory. (2008, January 16). Identification Of A Novel Neural Stem Cell Type. ScienceDaily. Retrieved September 2, 2015 from www.sciencedaily.com/releases/2008/01/080114173921.htm
Cold Spring Harbor Laboratory. "Identification Of A Novel Neural Stem Cell Type." ScienceDaily. www.sciencedaily.com/releases/2008/01/080114173921.htm (accessed September 2, 2015).

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