Featured Research

from universities, journals, and other organizations

Identification Of A Novel Neural Stem Cell Type

Date:
January 16, 2008
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells. In culture, neural stem cells (NSCs) can readily differentiate into neuronal and glial subtypes, but their ability to differentiate into region-specific neuronal cell types is limited.

Researchers from the Sloan-Kettering Institute, led by Dr. Lorenz Studer, have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells.

In culture, neural stem cells (NSCs) can readily differentiate into neuronal and glial subtypes, but their ability to differentiate into region-specific neuronal cell types is limited. Dr. Studer and colleagues isolated and cloned a population of neural rosette cells (R-NSCs), which have an expanded neuronal subtype differentiation potential.

Dr. Studer and colleagues demonstrate that R-NSCs can differentiate along both the CNS and PNS lineages, and are capable of in vivo engraftment. Furthermore, the researchers identified biomarkers unique to the R-NSC type, as well as signaling pathways required for the maintenance of the R-NSC type.

"Our data suggest that R-NSCs may represent the first neural cell type capable of recreating the full cellular diversity of the mammalian nervous system. As such, R-NSCs should have a major impact for applications in regenerative medicine and have the potential to become the "embryonic stem cell equivalent" of the nervous system," explains Dr. Studer.

This research is published in a recent issue of Genes and Development.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Identification Of A Novel Neural Stem Cell Type." ScienceDaily. ScienceDaily, 16 January 2008. <www.sciencedaily.com/releases/2008/01/080114173921.htm>.
Cold Spring Harbor Laboratory. (2008, January 16). Identification Of A Novel Neural Stem Cell Type. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/01/080114173921.htm
Cold Spring Harbor Laboratory. "Identification Of A Novel Neural Stem Cell Type." ScienceDaily. www.sciencedaily.com/releases/2008/01/080114173921.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins