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Promising New Approach To Cadmium Induced Hepatoxicity: Cytoprotective Effect Of Midkine

Date:
January 17, 2008
Source:
World Journal of Gastroenterology
Summary:
Cadmium is a very toxic substance which causes serious damage in the kidney, liver, heart and testes. At present, there is no effective treatment for cadmium intoxication, and patients are given supportive treatment according to their symptoms. A research group in Turkey has found that midkine has a curative effect in cadmium induced toxicity in hepatocytes.

Cadmium comes from a wide variety of sources in the environment and from industry and is extremely toxic to humans. Environmental exposure can occur via the diet and drinking water.

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In chronic exposure, it also accumulates in the body, particularly in the kidneys and the liver. The liver acts as a detoxification organ. It filters the blood coming from the gastrointestinal tract and liver cells can be exposed to almost whole ingested and absorbed molecules and toxins at their highest concentrations through the portal vein.

At present, there is no effective treatment for cadmium intoxication other than symptomatic treatment. Some chelating compounds are used for this purpose.

A new research article addresses this problem. An understanding of the processes that ensure self-protection against toxic substances is essential for the development and application of new therapeutic regimens.

In research conducted in hepatocyte cell culture, cadmium exposure causes dose and time dependent damage in liver cells. Dr. Yazihan et al found cadmium intoxication stimulates secretion of midkine in a dose and time dependent manner.

Midkine is mitogenic to cells. Midkine expression is found in the liver from early gestation. It is a heparin binding growth factor that regulates cell growth, survival, and differentiation. In this study it was found that exogenous midkine application induces hepatocyte proliferation. Midkine treatment prevented apoptosis, lactate dehydrogenase leakage and cytotoxicity caused by cadmium exposure in Hep3B cells. Midkine secretion might be one of the self defense mechanisms of the hepatocytes.

The results of this study suggest a promising future therapy with midkine in cadmium induced hepatotoxicity. Midkine may also be beneficial to other hepatotoxic conditions.

Journal reference: Yazihan N, Ataoglu H, Akcil E, Yener B, Salman B, Aydin C. Midkine secretion protects Hep3B cells from cadmium induced cellular damage. World J Gastroenterol 2008; 14(1): 76-80  http://www.wjgnet.com/1007-9327/14/76.asp


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The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

World Journal of Gastroenterology. "Promising New Approach To Cadmium Induced Hepatoxicity: Cytoprotective Effect Of Midkine." ScienceDaily. ScienceDaily, 17 January 2008. <www.sciencedaily.com/releases/2008/01/080116093514.htm>.
World Journal of Gastroenterology. (2008, January 17). Promising New Approach To Cadmium Induced Hepatoxicity: Cytoprotective Effect Of Midkine. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2008/01/080116093514.htm
World Journal of Gastroenterology. "Promising New Approach To Cadmium Induced Hepatoxicity: Cytoprotective Effect Of Midkine." ScienceDaily. www.sciencedaily.com/releases/2008/01/080116093514.htm (accessed November 27, 2014).

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