Featured Research

from universities, journals, and other organizations

Disparities Among Patients With Extremity Soft-tissue Sarcomas

Date:
January 24, 2008
Source:
Wiley-Blackwell
Summary:
A new study reveals significant racial and ethnic differences in the treatment and survival of patients with soft-tissue sarcomas, a rare but dangerous cancer that begins in muscle, fat, blood vessels or other supporting tissue of the body.

A new study reveals significant racial and ethnic differences in the treatment and survival of patients with soft-tissue sarcomas, a rare but dangerous cancer that begins in muscle, fat, blood vessels or other supporting tissue of the body.

Related Articles


While racial and ethnic disparities in treatment and disease outcomes have been reported for various cancers, this is the first study to address disparities in extremity soft-tissue sarcomas. Extremity soft-tissue sarcomas affect approximately 9,220 patients in the United States, more than half of which are estimated to involve an upper or lower extremity.

Preserving limbs with surgery is the accepted standard treatment for adult extremity soft tissue sarcomas. Amputation is seldom necessary because radiation therapy, given either before or after surgery, can effectively preserve limbs in up to 91 percent of cases. However, the research showed that this doesn't always happen for all patients.

Utilizing a database of the National Cancer Institute, Dr. Steve R. Martinez, a surgical oncologist with UC Davis Cancer Center and lead author of the study, and Dr. Anthony S. Robbins of the California Cancer Registry, mined the Surveillance, Epidemiology and End Results (SEER)-Medicare database and identified adult patients in the United States with extremity soft-tissue sarcomas who were diagnosed and treated between 1988 and 2003. Eligible patients included 4,636 whites, 663 blacks, 696 Hispanics and 411 Asians. Comparisons of treatments and survival were then made for each population.

The authors found that blacks had significantly lower rates of surgeries that would have saved their arm or leg, they had the highest rates of amputations, and they were the least likely to receive additional treatments that would lead to improved survival. The study found when compared with whites, blacks had a 39 percent higher death rate related to their disease, even when taking into account various factors known to influence sarcoma-specific survival.

In their analysis, the researchers also found that Hispanics tended to be diagnosed with extremity soft-tissue sarcomas at a younger age than whites, blacks, and Asians; blacks, Hispanics, and Asians tended to have larger tumors than whites; Asians were most likely to undergo limb-sparing procedures, and had the lowest rates of amputation; and Hispanics had lower rates of limb preservation and higher rates of amputation when compared with whites.

Martinez said that the study does not address the reasons for the different outcomes for patients with the same disease, but added that his study should be a wake-up call for physicians treating soft-tissue sarcomas.

"We need to take a close look at the factors that lead to worse results for one population when compared to others," he said. "And we need to focus our efforts toward improving extremity soft-tissue sarcoma treatment and outcomes for all patients, especially for those most at risk."

Journal article: "Racial and Ethnic Differences in Treatment and Survival Among Adults With Primary Extremity Soft-Tissue Sarcoma" Steve R. Martinez, Anthony S. Robbins, Frederick J. Meyers, Richard J. Bold, Vijay P. Khatri and James E. Goodnight. Cancer; Published Online: January 22, 2008 (DOI: 10.1002/cncr.23261); Print Issue Date: March 1, 2008.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Disparities Among Patients With Extremity Soft-tissue Sarcomas." ScienceDaily. ScienceDaily, 24 January 2008. <www.sciencedaily.com/releases/2008/01/080122101937.htm>.
Wiley-Blackwell. (2008, January 24). Disparities Among Patients With Extremity Soft-tissue Sarcomas. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/01/080122101937.htm
Wiley-Blackwell. "Disparities Among Patients With Extremity Soft-tissue Sarcomas." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122101937.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins