Featured Research

from universities, journals, and other organizations

Searching For Amyloid Interactions

Date:
January 25, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have undertaken a large-scale investigation into the molecular environment of the amyloid precursor protein (APP), a protein centrally associated with Alzheimer's disease.

Graph displaying the range of biological variation of the platelet proteome overlaid on a colored 2D-gel used to measure platelet protein expression.
Credit: Rudolf Oehler, Medical University of Vienna

Researchers have undertaken a large-scale investigation into the molecular environment of the amyloid precursor protein (APP), a protein centrally associated with Alzheimer's disease.

A defining hallmark of Alzheimer's is the extracellular accumulation of amyloid plaques in the diseased brain. These plaques arise from the cleavage of APP, which generates short, sticky fragments called amyloid B-peptides. Despite intense research efforts, however, the function of APP remains enigmatic and only a few proteins are known to interact with it.

Gerold Schmitt-Ulms and colleagues employed a technique called 'time-controlled transcardiac perfusion cross-linking" to uncover more APP-interacting proteins. They pumped a chemical through a mouse's body that would permanently cross-link any proteins that were in close proximity. They could then fish out APP from the brain and study what it was linked to.

From their perfusion, Schmitt-Ulms and colleagues confirmed eight previously reported APP interactions and also identified over 30 new, potentially interacting proteins. They also mapped the interactions of two proteins related to APP that are not known to cause disease, to sense which interactions the three related proteins had in common and which were APP-specific; interestingly the majority of the potential binding partners were specific to APP.

This work constitutes the most comprehensive analysis of the APP interactome to date and may finally shed light on the functional roles of APP in the brain. The researchers believe further investigations of these new interactions may reveal an "Achilles' heel" in the biology of APP that can be exploited for diagnosis or therapy.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Searching For Amyloid Interactions." ScienceDaily. ScienceDaily, 25 January 2008. <www.sciencedaily.com/releases/2008/01/080122154805.htm>.
American Society for Biochemistry and Molecular Biology. (2008, January 25). Searching For Amyloid Interactions. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2008/01/080122154805.htm
American Society for Biochemistry and Molecular Biology. "Searching For Amyloid Interactions." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122154805.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins