Featured Research

from universities, journals, and other organizations

Low Variation In Platelet Protein Expression Within The Elderly

Date:
January 22, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
The variation in human platelets in the elderly population is not significantly large, report researchers in a study that has strong implications for clinical biomarker research.

The variation in human platelets in the elderly population is not significantly large, report researchers in a study that has strong implications for clinical biomarker research.

The onset or progression of diseases like cancer is accompanied by changes in the expression of specific proteins. These proteins could be used as biomarkers to diagnose patients early or track therapy progression. However, identifying clinical biomarkers requires knowing the extent of natural protein variation in the population, which arises from a combination of factors like age, gender, and genetic background.

Rudolf Oehler and colleagues examined the platelet protein variation in 20 individuals aged 56-100, an age group at higher for many diseases. Interestingly, while their analysis had a 7% variation from technical accuracy, the total variation was only 18%, although a few proteins did show dramatic differences.

Since the variation of protein expression in normal platelets is fairly low, any changes in protein expression associated with disease will likely also be small (i.e. a low expression range in a healthy population means you don't need big changes to perturb the system).

Platelets play a key role in maintaining the health of our blood and since they're easy to extract they may be a valuable source for protein biomarkers. Due to the naturally low variation, though, Oehler and colleagues note that finding these biomarkers requires highly sensitive and accurate equipment.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Low Variation In Platelet Protein Expression Within The Elderly." ScienceDaily. ScienceDaily, 22 January 2008. <www.sciencedaily.com/releases/2008/01/080122154845.htm>.
American Society for Biochemistry and Molecular Biology. (2008, January 22). Low Variation In Platelet Protein Expression Within The Elderly. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2008/01/080122154845.htm
American Society for Biochemistry and Molecular Biology. "Low Variation In Platelet Protein Expression Within The Elderly." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122154845.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins