Featured Research

from universities, journals, and other organizations

Low Variation In Platelet Protein Expression Within The Elderly

Date:
January 22, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
The variation in human platelets in the elderly population is not significantly large, report researchers in a study that has strong implications for clinical biomarker research.

The variation in human platelets in the elderly population is not significantly large, report researchers in a study that has strong implications for clinical biomarker research.

Related Articles


The onset or progression of diseases like cancer is accompanied by changes in the expression of specific proteins. These proteins could be used as biomarkers to diagnose patients early or track therapy progression. However, identifying clinical biomarkers requires knowing the extent of natural protein variation in the population, which arises from a combination of factors like age, gender, and genetic background.

Rudolf Oehler and colleagues examined the platelet protein variation in 20 individuals aged 56-100, an age group at higher for many diseases. Interestingly, while their analysis had a 7% variation from technical accuracy, the total variation was only 18%, although a few proteins did show dramatic differences.

Since the variation of protein expression in normal platelets is fairly low, any changes in protein expression associated with disease will likely also be small (i.e. a low expression range in a healthy population means you don't need big changes to perturb the system).

Platelets play a key role in maintaining the health of our blood and since they're easy to extract they may be a valuable source for protein biomarkers. Due to the naturally low variation, though, Oehler and colleagues note that finding these biomarkers requires highly sensitive and accurate equipment.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Low Variation In Platelet Protein Expression Within The Elderly." ScienceDaily. ScienceDaily, 22 January 2008. <www.sciencedaily.com/releases/2008/01/080122154845.htm>.
American Society for Biochemistry and Molecular Biology. (2008, January 22). Low Variation In Platelet Protein Expression Within The Elderly. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2008/01/080122154845.htm
American Society for Biochemistry and Molecular Biology. "Low Variation In Platelet Protein Expression Within The Elderly." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122154845.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins