Featured Research

from universities, journals, and other organizations

Key Factor In Stress Effects On The Brain Identified

Date:
January 26, 2008
Source:
Yale University
Summary:
Acute and chronic stress can have devastating effects on the brain, and researchers have now pinpointed one receptor that plays a key role in that harmful cycle. Uncontrollable stress is a major contributing factor for neuropsychiatric disorders such as major depression and post-traumatic stress disorders, which have been linked to cellular changes in the hippocampus. The hippocampus is a part of the brain that is particularly susceptible to stress.

Acute and chronic stress can have devastating effects on the brain, and Yale School of Medicine researchers have pinpointed one receptor that plays a key role in that harmful cycle.

“This could provide new targets for the development of antidepressant medications,” said Ronald Duman, professor of psychiatry and pharmacology and senior author of the study.

Duman said uncontrollable stress is a major contributing factor for neuropsychiatric disorders such as major depression and post-traumatic stress disorders, which have been linked to cellular changes in the hippocampus. The hippocampus is a part of the brain that is particularly susceptible to stress.

But little is known about the underlying mechanisms that block the growth of new neurons, which are needed for antidepressants to be effective in treating depression and anxiety.

The researchers discovered in this mouse study that when activated, the receptor for IL-1ß prevents the brain from creating new neurons. It also decreased the animals’ preference for a sweetened solution, a response that mirrors the inability to feel pleasure that people experience with depression.

IL-1ß is a cytokine—or signaling compound—that promotes inflammation. Previous animal studies showed that exposure to stress increases IL-1ß in several brain areas, including the hippocampus. It also has been demonstrated that administering IL-1ß produces several stress-like effects in the hypothalamus, pituitary, and adrenal system as well as the hippocampus.

The team blocked the effects of IL-1ß with an inhibitor, resulting in blockade of cell cycle arrest.

“This is the first study to show how IL-1ß—when activated by acute and chronic stress—arrests the cell cycle,” said Ronald Duman, professor of psychiatry and pharmacology.

Journal reference: PNAS 105: 751-756 (January 15, 2008). Ja Wook Koo of Yale is lead author of the paper.

The U.S. Public Health Service grants, a Veterans Administration National Center Grant for Post-Traumatic Stress Disorder, and the Connecticut Mental Health Center supported the research.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Key Factor In Stress Effects On The Brain Identified." ScienceDaily. ScienceDaily, 26 January 2008. <www.sciencedaily.com/releases/2008/01/080123100328.htm>.
Yale University. (2008, January 26). Key Factor In Stress Effects On The Brain Identified. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2008/01/080123100328.htm
Yale University. "Key Factor In Stress Effects On The Brain Identified." ScienceDaily. www.sciencedaily.com/releases/2008/01/080123100328.htm (accessed August 21, 2014).

Share This




More Mind & Brain News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) — Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) — Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) — A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins