Featured Research

from universities, journals, and other organizations

Key Factor In Stress Effects On The Brain Identified

Date:
January 26, 2008
Source:
Yale University
Summary:
Acute and chronic stress can have devastating effects on the brain, and researchers have now pinpointed one receptor that plays a key role in that harmful cycle. Uncontrollable stress is a major contributing factor for neuropsychiatric disorders such as major depression and post-traumatic stress disorders, which have been linked to cellular changes in the hippocampus. The hippocampus is a part of the brain that is particularly susceptible to stress.

Acute and chronic stress can have devastating effects on the brain, and Yale School of Medicine researchers have pinpointed one receptor that plays a key role in that harmful cycle.

Related Articles


“This could provide new targets for the development of antidepressant medications,” said Ronald Duman, professor of psychiatry and pharmacology and senior author of the study.

Duman said uncontrollable stress is a major contributing factor for neuropsychiatric disorders such as major depression and post-traumatic stress disorders, which have been linked to cellular changes in the hippocampus. The hippocampus is a part of the brain that is particularly susceptible to stress.

But little is known about the underlying mechanisms that block the growth of new neurons, which are needed for antidepressants to be effective in treating depression and anxiety.

The researchers discovered in this mouse study that when activated, the receptor for IL-1 prevents the brain from creating new neurons. It also decreased the animals’ preference for a sweetened solution, a response that mirrors the inability to feel pleasure that people experience with depression.

IL-1 is a cytokine—or signaling compound—that promotes inflammation. Previous animal studies showed that exposure to stress increases IL-1 in several brain areas, including the hippocampus. It also has been demonstrated that administering IL-1 produces several stress-like effects in the hypothalamus, pituitary, and adrenal system as well as the hippocampus.

The team blocked the effects of IL-1 with an inhibitor, resulting in blockade of cell cycle arrest.

“This is the first study to show how IL-1—when activated by acute and chronic stress—arrests the cell cycle,” said Ronald Duman, professor of psychiatry and pharmacology.

Journal reference: PNAS 105: 751-756 (January 15, 2008). Ja Wook Koo of Yale is lead author of the paper.

The U.S. Public Health Service grants, a Veterans Administration National Center Grant for Post-Traumatic Stress Disorder, and the Connecticut Mental Health Center supported the research.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Key Factor In Stress Effects On The Brain Identified." ScienceDaily. ScienceDaily, 26 January 2008. <www.sciencedaily.com/releases/2008/01/080123100328.htm>.
Yale University. (2008, January 26). Key Factor In Stress Effects On The Brain Identified. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2008/01/080123100328.htm
Yale University. "Key Factor In Stress Effects On The Brain Identified." ScienceDaily. www.sciencedaily.com/releases/2008/01/080123100328.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Binge-Watching TV Linked To Loneliness

Binge-Watching TV Linked To Loneliness

Newsy (Jan. 29, 2015) Researchers at University of Texas at Austin found a link between binge-watching TV shows and feelings of loneliness and depression. Video provided by Newsy
Powered by NewsLook.com
Signs You Might Be The Passive Aggressive Friend

Signs You Might Be The Passive Aggressive Friend

BuzzFeed (Jan. 28, 2015) "No, I&apos;m not mad. Why, are you mad?" Video provided by BuzzFeed
Powered by NewsLook.com
City Divided: A Look at Model Schools in the TDSB

City Divided: A Look at Model Schools in the TDSB

The Toronto Star (Jan. 27, 2015) Model schools are rethinking how they engage with the community to help enhance the lives of the students and their parents. Video provided by The Toronto Star
Powered by NewsLook.com
Man Saves Pennies For 65 Years

Man Saves Pennies For 65 Years

Rooftop Comedy (Jan. 26, 2015) A man in Texas saved every penny he found for 65 years, and this week he finally cashed them in. Bank tellers at Prosperity Bank in Slaton, Texas were shocked when Ira Keys arrived at their bank with over 500 pounds of loose pennies stored in coffee cans. After more than an hour of sorting and counting, it turned out the 81 year-old was in possession of 81,600 pennies, or $816. And he&apos;s got more at home! Video provided by Rooftop Comedy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins