Featured Research

from universities, journals, and other organizations

Genetic Link To One Form Of Common Pediatric Illness -- Inflammation Of The Middle Ear

Date:
January 26, 2008
Source:
Journal of Clinical Investigation
Summary:
Inflammation of the middle ear (otitis media) is one of the most common pediatric ailments. Young children are particularly prone to otitis media as their Eustachian tubes, which regulate the pressure in the middle ear, have not yet fully developed. In many instances it is accompanied by an acute ear infection and can be resolved by a course of antibiotics.

Inflammation of the middle ear (otitis media) is one of the most common pediatric ailments. Young children are particularly prone to otitis media as their Eustachian tubes, which regulate the pressure in the middle ear, have not yet fully developed.

Related Articles


In many instances it is accompanied by an acute ear infection and can be resolved by a course of antibiotics.

However, other forms of the disease, e.g, otitis media with effusion, which occurs when fluid accumulates in the middle-ear cavity in the absence of an acute ear infection, are linked to auditory or eustachian tube dysfunction. This, in turn, is influenced by poorly understood factors, including genetics.

In a new study, J. G. Seidman and colleagues at Harvard Medical School in Boston, found that removing the Eya4 gene in mice caused malformation of the Eustachian tube as well as otitis media with effusion. The authors therefore suggested that EYA4 mutations might predispose individuals to otitis media with effusion.

As discussed in an accompanying commentary by Evelyn Lazaridis and James Saunders at the University of Pennsylvania, Philadelphia, this description of a genetic model of otitis media with effusion should aid in the development of therapeutics for this condition, frequent recurrence of which is accompanied by an increased risk for sustained conductive hearing loss, with the potential for speech, language, and learning problems.

The article "Eya4-deficient mice are a model for heritable otitis media" is published in the Journal of Clinical Investigation January 24, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Genetic Link To One Form Of Common Pediatric Illness -- Inflammation Of The Middle Ear." ScienceDaily. ScienceDaily, 26 January 2008. <www.sciencedaily.com/releases/2008/01/080124173806.htm>.
Journal of Clinical Investigation. (2008, January 26). Genetic Link To One Form Of Common Pediatric Illness -- Inflammation Of The Middle Ear. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/01/080124173806.htm
Journal of Clinical Investigation. "Genetic Link To One Form Of Common Pediatric Illness -- Inflammation Of The Middle Ear." ScienceDaily. www.sciencedaily.com/releases/2008/01/080124173806.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins