Featured Research

from universities, journals, and other organizations

Turning On Adult Stem Cells May Help Repair Bone

Date:
January 25, 2008
Source:
Massachusetts General Hospital
Summary:
The use of a drug to activate stem cells that differentiate into bone appears to cause regeneration of bone tissue and be may be a potential treatment strategy for osteoporosis.

The use of a drug to activate stem cells that differentiate into bone appears to cause regeneration of bone tissue and be may be a potential treatment strategy for osteoporosis, according to a new report. The study -- led by researchers from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute (HSCI) -- found that treatment with a medication used to treat bone marrow cancer improved bone density in a mouse model of osteoporosis, apparently through its effect on the mesenchymal stem cells (MSCs) that differentiate into several types of tissues.

"Stem cell therapies are often thought of as putting new cells into the body, but this study suggests that medications can turn on existing stem cells that reside in the body's tissues, acting as regenerative medicines to enhance the body's own repair mechanisms," says David Scadden, MD, director of the MGH Center for Regenerative Medicine and HSCI co-director. "Drugs that direct immature cells to become a particular cell type, like in this study, could potentially be very useful."

The study was designed to examine whether the drug bortezamib (Bzb), which can alleviate bone destruction associated with the cancer multiple myeloma, could also regenerate bone damaged by non-cancerous conditions. In their first experiments, the researchers showed that treating mice with Bzb increased several factors associated with bone formation. Similar results were seen when cultured MSCs were treated with Bzb, but not when the drug was applied to cells that were committed to become particular cell types. Found in the bone marrow, MSCs have the potential to develop into the bone-building osteoblasts and several other types of cells -- including cartilage, fat, skin and muscle.

Subsequent experiments supported the hypothesis that Bzb increases osteoblast activity and bone formation by acting on MSCs but not on more differentiated osteoblast precursors. Use of Bzb to treat a mouse model of menopausal osteoporosis produced significant improvements in bone formation and density. Since current treatments for osteoporosis -- which target differentiated cells like osteoblasts and the osteoclasts that break down bone -- have limitations, the ability to direct differentiation of MSCs could be a promising approach to treating osteoporosis and cancer-associated bone loss, the researchers note.

"If the paradigm displayed in this study holds true for other tissues, we may have options for repairing and regenerating sites affected by injury or disease with medications -- that would be pretty exciting." says Scadden, who is the Gerald and Darlene Jordan Professor of Medicine at Harvard Medical School.

The article "Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice" was published in the February 2008 issue of the Journal of Clinical Investigation.

Siddhartha Mukherjee, MD, of the MGH Center for Regenerative Medicine (CRM) and HSCI is lead author of the study, which was supported by grants from the National Institutes of Health. Additional co-authors are Jesse Schoonmaker, David Seo, Joshua Aronson, and Louise Purton, PhD, MGH-CRM; Noopur Raje, MD, MB, MGH Cancer Center; Julie Liu, Jane Lian, PhD, and Gary Stein, PhD, University of Massachusetts Medical School; Teru Hideshima, MD, PhD, Sonia Vallet, MD, Samantha Pozzi, Shweta Chhetry, Mariateresa Fulciniti and Kenneth Anderson, MD, Dana-Farber Cancer Institute; Marc Wein, Dallas Jone, PhD, and Laurie Glimcher, MD, Harvard School of Public Health; and Mary Bouxsein, PhD, Beth Israel Deaconess Medical Center.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Turning On Adult Stem Cells May Help Repair Bone." ScienceDaily. ScienceDaily, 25 January 2008. <www.sciencedaily.com/releases/2008/01/080124173809.htm>.
Massachusetts General Hospital. (2008, January 25). Turning On Adult Stem Cells May Help Repair Bone. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/01/080124173809.htm
Massachusetts General Hospital. "Turning On Adult Stem Cells May Help Repair Bone." ScienceDaily. www.sciencedaily.com/releases/2008/01/080124173809.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins