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TNF-alpha Antagonist Stops Inflammation-induced Colon Cancer In Its Tracks

Date:
January 29, 2008
Source:
Journal of Clinical Investigation
Summary:
Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data have identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice induced to have inflammatory bowel disease. These data provide clear rationale for the idea that drugs antagonizing TNF-alpha (such as those used to treat rheumatoid arthritis) might reduce the risk of colon cancer in individuals with UC.
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FULL STORY

Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer.

New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice in which inflammation of the bowel was induced by administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion.

Expression of TNF-alpha was increased in the colon of normal mice treated with AOM and DSS and this was followed by the development of tumors in the colon.

Mice lacking one of the receptors for TNF-alpha and mice treated with an antagonist of TNF-alpha were markedly protected from the effects of treatment with AOM and DSS, developing less inflammation of the colon and fewer tumors in the colon.

As suggested by the authors, and by Ezra Burstein and Eric R. Fearon in an accompanying commentary, these data provide clear rationale for the idea that drugs antagonizing TNF-alpha (such as those used to treat individuals with rheumatoid arthritis) might be useful in reducing the risk of colon cancer in individuals with ulcerative colitis.

The article "Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis" was recently published in the Journal of Clinical Investigation.


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "TNF-alpha Antagonist Stops Inflammation-induced Colon Cancer In Its Tracks." ScienceDaily. ScienceDaily, 29 January 2008. <www.sciencedaily.com/releases/2008/01/080124173812.htm>.
Journal of Clinical Investigation. (2008, January 29). TNF-alpha Antagonist Stops Inflammation-induced Colon Cancer In Its Tracks. ScienceDaily. Retrieved May 28, 2015 from www.sciencedaily.com/releases/2008/01/080124173812.htm
Journal of Clinical Investigation. "TNF-alpha Antagonist Stops Inflammation-induced Colon Cancer In Its Tracks." ScienceDaily. www.sciencedaily.com/releases/2008/01/080124173812.htm (accessed May 28, 2015).

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